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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA

DOI: https://doi.org/10.1016/j.molcel.2019.02.024

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Abstract:

? Hypomethylated DNA preserves nearly complete catalogs of developmental enhancers ? Adult H3K4me1 +H3K27ac ? enhancers are not poised but remnants of fetal gene activity ? TFs relieved of PRC2 repression selectively reactivate hypomethylated enhancers ? Recommissioned enhancers drive tissue-specific fetal and embryonic gene activit

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