Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

？ Chromatin modifiers Kismet and Trr limit intestinal stem cell proliferation ？ Kismet and Trr colocalize at transcriptionally active regions and co-regulate genes ？ EGFR negative regulator Cbl is a target gene of Kismet and Trr ？ Kismet and Trr limit EGFR signaling in ISCs, preventing tumor-like ISC accumulatio