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-  2019 

GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion

DOI: https://doi.org/10.1016/j.devcel.2019.02.011

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Abstract:

? PERK pathway is required for the production of mIL-1β from proIL-1β ? Loss of GRASP55 causes mIL-1β aggregation and affects mIL-1β secretion ? IRE1α inhibition causes aggregation of mIL-1β and reduces mIL-1β secretion ? GRASP55 controls IRE1α activity in LPS-stimulated macrophage

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