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-  2019 

Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment

DOI: https://doi.org/10.1016/j.devcel.2019.02.023

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Abstract:

? Cell attachment is required for chemical-induced cytoskeleton polarization ? Cell attachment induces local PM curvature increase to recruit and polarize SRGAP2 ? Polarized SRGAP2 induces sequential polarization of PtdIns4P, PIP5K1C90, and pMLC ? This SRGAP2 polarization signaling axis regulates neutrophil firm adhesio

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