An Intrinsically Disordered Region in OSBP Acts as an Entropic Barrier to Control Protein Dynamics and Orientation at Membrane Contact Sites

？ OSBP contains an N-terminal intrinsically disordered region (N-ter) ？ The N-ter limits OSBP membrane density without affecting affinity for PI(4)P ？ By limiting OSBP surface density, the N-ter facilitates OSBP in-plane diffusion ？ The N-ter also controls OSBP orientation at membrane contact site