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-  2019 

Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics

DOI: https://doi.org/10.1016/j.cels.2019.02.002

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Abstract:

? Single-cell phenotypic analysis reveals detailed replicative aging dynamics ? Isogenic cells differentiate early in life toward two distinct aging paths ? A stochastic state-transition model captures the landscape of aging dynamics ? Genetic and environmental factors modulate aging trajectories and kinetic

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