New Insights into the Regulation of Leptin Gene Expression

Leptin is a key hormone in the homeostatic regulation of body weight. While past research focused mainly on overall leptin actions, a recent study by Dallner et al. (2019) Dallner O.S. Marinis J.M. Lu Y.H. Birsoy K. Werner E. Fayzikhodjaeva G. Dill B.D. Molina H. Moscati A. Kutalik Z. et al. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity. Nat. Med. 2019; 25 : 507-516 Crossref Scopus (2) Google Scholar takes a fresh look at the regulatory elements of the leptin gene locus, providing new insights into processes that modulate leptin levels