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- 2019
Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic CardiomyopathyDOI: https://doi.org/10.1016/j.cmet.2019.01.005 Abstract: ？ Fatty acids upregulate GSK-3α, which in turn phosphorylates PPARα at Ser280 ？ Ser280 phosphorylation stimulates biased gene expression, favoring fatty acid uptake ？ PPARα-Ser280 phosphorylation promotes the development of lipotoxic cardiomyopathy ？ Fibrates inhibit Ser280 phosphorylation, thereby reversing cardiac lipotoxicit
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