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- 2019
De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell CarcinomaDOI: https://doi.org/10.1016/j.stem.2019.01.003 Abstract: ？ De novo Pitx1 expression defines tumor-propagating SCC cells ？ PITX1 governs a feed-forward circuit that enables TPC-renewal and clonal expansion ？ PITX1 function represses KLF4-dependent squamous differentiation ？ Pitx1 expression and function are restricted by KLF4 activit
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