Histomorphometric Evaluation of Bone Regeneration in Peri-Implant Osseous Defects Treated With Titanium Prepared Platelet Rich Fibrin: An Experimental Study in a Rabbit Model

Aim: The present study aims to investigate the healing of artificially created peri-implant osseous defects using Titanium-Platelet Rich Fibrin Material and Method: Bone defects (9-mm diameter, 4-mm depth) were created and implant beds (3-mm diameter, 6-mm depth) were prepared in the middle of them in rabbit tibias (24 rabbits) used as the experimental model. Afterwards, dental implants were installed into the left and right tibia (diameter 3.0 mm, length 8 mm). In the experimental groups, the peri-implant defect was filled with Autogenous grafts (AG), Titanium-Platelet Rich Fibrin (T-PRF), Biphasic Calcium Phosphate grafts (BCP). The control group did not receive any filling. The bone-to-implant contact (BIC) was obtained by histomorphometrically examining the sections taken from the study groups. Results: AG group was resulted in a high degree of BIC. No difference of statistical significance was found for the BIC as far as autogenous graft and PRF groups are concerned. Conclusion: Peri-implantal defects in regeneration of T-PRF were found to be nearly as affective as the autogenous bone graft. We, therefore, conclude that T-PRF can be used for guided bone regeneration in the function of autogenic matrix in the future