Investigation of the Effects of Magnesium Sulfate Therapy on Recovery in Traumatic Brain Injury

Aim The incidence of disability and mortality in traumatic brain injuries is high. However there are no proven pharmacologic therapies to prevent these injury. Magnesium plays central pathophysiological role in trumatic brain injuries. It has been shown that reduced magnesium levels were associated with these injuries. In this study, we investigate the effects of magnesium sulphate in traumatic brain injuries. Material and Methods 60 traumatic brain injury patients admitted to Antalya E？itim ve Ara？t？rma Hospital between November 2008 and November2016 were retrospectively analysed. Results. 60 patients were included in this study (mean age 35.6±17.6 years, 53 male, 7 female). GCS scores were 5 at admission, 7 at the time of discharge in Magnesium Sulphate and control groups, and at the end of two months it was 12 in Magnesium Sulphate group and 9 in control group (P<0.05). Duration in intensive care unit stay was 7 days in both groups. Surgical decompression was performed in 6 (20%) of the Magnesium Sulfate and in 8 of the control group (26.6%). Magnesium administered patients showed a significant positive effect on recovery after 2 months (P<0.05). Mortality after discharge within 1 month was 1 patient (3.33%) in Magnesium Sulfate group and 3 (10%) patients with control group. Conclusion The results indicate that administration og magnesium sulphate within 12 hours of traumatic brain injury may have neuroprotecitve effects