The Relationship Between Insulin Resistance And Thyroid Disorders

Abstract Aim: There are researches that the thyroid disorders effect carbonhydrate metabolizm and the insulin resistance causes impaired glucose tolerance, diabetes, dyslipidemia, obesity, metabolic syndrome and hypertension. The purpose ofthis study is; to investigate whether thyroid disorders are related to insulin resistance and to investigate what family physicians may do before complications develop. Methods: After the approval of the ethics committee, 2000 patients (age 18-85 years) were evaluated retrospectively and 301 patients were included in the study. According to the diagnosis the patients were grouped as hypothyroid, hyperthyroid and euthyroid. TSH, fT3, fT4, insulin,FPG, HbA1c, anti-TG, anti-TPO were recorded. HOMA-IRs were calculated. Results: Of the patients, 264 (87.7%) were female and37 (12.3%) were male. 45.8% of the patients were hypothy-roid, 19.6% were hyperthyroid and 34.6% were euthyroid.95.6% of hypothyroid ones and 93.2% of hyperthyroid oneswere receiving treatment. 29.6% of the patients’ FPG were between 100-126 mg/dl. HOMA-IR ≥ 2.5 in 49.6% of thepatients. In 34.9% of patients HBA1C was detected as bet-ween 5.7-6.4%. 48.6% of the hypothyroid group, 52.5% ofthe hyperthyroid group and 48.1% of the euthyroid group had HOMA-IR ≥ 2.5. There were no significant correlation and significant difference between insulin resistance andany of the hypothyroid, hyperthyroid and euthyroid patients.There was a significant difference for anti-TG and anti-TPO in the groups. There was a significant positive correlation between HOMA-IR and TSH, and a negative correlation bet-ween TSH and sT4. Conclusion: Treatment of thyroid disorders may preventthe development of insulin resistance and / or progressionto diseases such as T2DM, obesity, metabolic syndrome. Monitoring metabolic parameters in thyroid disorders’ follow-up may be clinically important. In this way, a common etio-logical factor such as insulin resistance and many public health problems can be avoided, and / or the course can be slowed down