A new method in foreseeing late-period neuro-psychosis in carbon monoxide poisoning: COHb/Troponin, COHb/Neutrophil, and COHb/ Lymphocyte

Objective: Carbon monoxide(CO) poisoning is one of the most common reasons of poisoning and death in the world. Evaluation for the effects of CO poisoning, carboxyhaemoglobin(COHb), troponin(cTn), neutrophil, lymphocyte and their rates-which are COHb/cTn rate(COTR), COHb/neutrophil rate(CONR), COHb/lymphocyte rate(COLR) in terms of Neuro-Psychosis(NP) and mortality is aimed. Method: 1229 patients who consulted our hospital’s Emergency Department(ED) from January 2005 to December 2008, due to CO poisoning were included in this sectional cohort study. The patients were divided into two groups, NP positive(NP+) and NP negative(NP-), according to their NP groups. They were compared in terms of COHb, cTn, neutrophil, lymphocyte, COTR, CONR, COLR, age, gender, NP, and mortality rates. Results: 466(%40,9) members of the group NP(-) were males and the other 673(%59,1) members were females. Therewithal, 22(%24,4) members of the group NP(+) were males and the other 68(%75,6) members were females. Red Cell Distribution Width(RDW), Mean Platelet Volume(MPV), neutrophil, lymphocyte, COHb, troponin, COTR, CONR and COLR levels were high in group NP(+). NP was significant in terms of gender and mortality values. The analysis of gender between NP, mortality and the other variables was statistically significant. COTR, CONR, and COLR were statistically significant in Spearman analysis. Sensitivity and specificity values of COTR, CONR, COLR in NP and mortality ROC curve analysis were also found to be significant. Conclusions: The high levels of COTR, CONR, and COLR at CO poisoning may be predictive and supportive values in terms of 'complications during and after poisoning', NP and mortality