Daily Dose Dependent Effects of Fluoxetine-HCl (FLX) on Heart Tissue of Zebrafish (Danio rerio Hamilton, 1822)

The aim of this study is to investigate the daily dose dependent effects of Fluoxetine-HCl (FLX) on antioxidant enzymes (CAT, GSH), lipid peroxidation levels (MDA) and total protein (TP) levels of zebrafish heart tissue. FLX is the active compound of the antidepressant Prozac？. FLX acts as a selective serotonin reuptake inhibitor (SSRI) in humans. This study was planned as a model to investigate the dose dependent effects of daily intake doses of FLX, which adapted from human proportionally to weight of zebrafish. Biochemical analyses catalase (CAT), glutatyon (GSH), lipid peroksidasyon levels (MDA) and total protein (TP) were detected using spectrophotometric methods. In this study, there was not found any negative effects of FLX on catalase and glutation activity, malondialdehyde levels and total protein levels of zebrafish heart tissue during specified periods