Molecular Approach to Pediatric Precursor B-ALL

Leukemia is the most common malignant disease in childhood. This disease was identified almost 150 years ago, but in the last 30 years, treatment processes have achieved a success rate of up to 90%. These successful outcomes were supported by multi-drug treatments, central nervous system prophylaxis, maintainability and therapeutic applications. Although successful treatment outcome relapse continues to be a risk for leukemia and is seen in 20% of patients with leukemia. In this case, all other types of cancers as well as leukemia have a structure that is heterogeneous. Therefore, individualized treatment methods are more effective than early accurate diagnosis, hence the development of individualised treatment methods and intervention strategies have become necessary. In this context, as in all other types of cancer the leukemia genome contain structural abnormalities several genes leading to their functional dysfunction. These genes have the potential to become novel biomarkers for diagnosis, prognosis, treatment and prevention of relapse