Investigation of Prevalence, Isolated Microorganisms and Antibiotic Resistance in Cultured Late Neonatal Sepsis Cases

Objective: The factors causing newborn sepsis and antibiotic resistance may differ according to the units. This study aimed to investigate the demographic characteristics, risk factors, causative microorganisms and antibiotic resistance of infants followed up with neonatal sepsis in our neonatal intensive care unit. Materials and Methods: Between January 2015 and March 2018, 4156 blood cultures sent from our hospital neonatal intensive care unit to the microbiology laboratory were evaluated with an automated blood culture system. Antibiotic susceptibility tests of isolated microorganisms were performed by Kirby-Bauer disc diffusion method. Cases with culture positive neonatal sepsis were included in the study (n = 237). These patients were divided into two groups as early-onset neonatal sepsis (ENS) and late-onset neonatal sepsis (GNS). The cases were analyzed by sex, birth weight and week, risk factors, clinical and laboratory findings, blood culture, active microorganism and antibiotic resistance. Results: During the study period, sepsis was observed in 237 (5.7%) cultures of 4156 infants who had blood culture. 237 babies treated with Sepsis were included in the study. 150 cases (63,2%) were diagnosed as late sepsis, 87 (36,7%) were diagnosed as early sepsis and 114 cases (77%) were premature. The most common microorganisms were Klebsiella pneumoniae (39,3%), Coagulase-negative staphylococci (14,0%), Escherichia coli (13,3%), and Acinetobacter baumanii (10,1%). Conclusion: The change of the sepsis factors and the gradual increase of resistant microorganisms are an important question. For this reason, it is important to determine the neonatal sepsis risk factors, common agents and antibiotic resistance in each newborn unit and make an empirical treatment plan according to these findings