Bilirubin Impriting Chitosan-Agarose Biomaterial Synthesis, Characterization and Use to Bilirubin Removal

Aim: This study was conducted to synthesize and characterize bilirubin imprinted chitosan-agarose biomaterial and to determine its significance on bilirubin removal. Method: Natural Chitosan and agarose polymers were chosen as materials. Human plasma was used to determine the capacity of bilirubin imprinted chitosan-agarose biomaterial for bilirubin removal. Findings: The optimum conditions for bilirubin removal were determined as pH 7.0 at 37oC with a starting concentration of 40 mg/g. An increase in NaCl concentration was shown to decrease the ionic strength for bilirubin. Conclusion: Bilirubin analysis was performed on serum samples taken before and after the interaction. A suspension rate of 87% was obtained by using molecular imprinted chitosan-agarose biomaterials. When bilirubin adsorption from aqueous solutions was compared to the adsorption of bilirubin from human plasma it was observed that the adsorption capacity of plasma was slightly decreased