Do uterine fibroids which are left to postmenopausa have any negative effects on the developing endometrial cancer?

Objective: Endometrial cancer and uterine leiomyoma are the most common malignant and benign tumors in developed countries. In women operated for endometrial cancer, accompanying uterine myome is observed in high rates. The treatment of the premenopausal myomas is delayed after the menopause conservatively. Yet it is unclear whether this approach has any negative effect on possible endometrial cancer. The goal of this study is to investigate the relationship between premenopausal myomas and the prognostic factors of endometrial cancer. Material and Method: The files of 127 patients who were operated between January 2005 and February 2011 in our hospital fulfilling the criteria were investigated retrospectively. Sociodemographic characteristics, obstetric traits, myoma presence, endometrial tumor presence, tumor grade, myometrial invasion grade were evaluated and significance was investigated. Results: Factors affecting the prognosis of endometrial carcinoma; age, histological type, histological grade and myometrial invasion were found to be not significantly related to myoma uteri. Conclusion: Endometrial cancer, the most common gynecologic cancer in women, and uterine myoma, the most common benign tumor, were investigated together. The histopathological prognostic findings of endometrial cancer are unchanged by the presence uterine myoma. Therefore we reached the conclusion that there is no negative impact on prognosis