The Investigation of Anti-Urease and Anti-Elastase Activities of Firstly Synthesized Eperezolide-like Derivatives

Antiurease and anti-elastase activities of the oxazolidinone derived eperezolid-like compounds which were synthesized for the first time were examined. The highest and lowest antiurease activity were observed in the compounds 8 (IC50 = 1.91x10-3 ± 2.97x10-4 μM) and 10 (IC50 = 6,03x10-3±1,98x10-4 μM), respectively. The highest and lowest anti-elastase activities were observed in compounds 8 (IC50 = 2,2x10-2 ± 2,6x10-3 μM) and 1 (IC50 = 4,1x10-2 ±1,3x10-3 μM), respectively