Protective Effect of Alpha Lipoic Acid on Methotrexate Damage

1950 Methotrexate (MTX) contains aminopterin as a carcinogen, based on antifolate therapy. MTX is a folic acid antagonist and an antineoplastic drug that inhibits DNA formation by inhibiting thymidylate synthetase at high doses. Basically, antimetabolite is a special antiinflammatory, antiproliferative, immunosuppressive, antipsychotic and clinically available indication. Unfortunately, with hepatotoxicity and nephrotoxicity, depending on the side effects, the drug is limited or the drug is discontinued. Studies have shown that oxidative damage caused by reactive oxygen radicals is responsible for the side effects of the drug as well as hepatotoxicity. This is a preferred solution that has emerged as a problem. The aim of the work is to compile protection against the disease. The aim of this paper was to emphasize the benefit of compiling studies investigating the protective effect of alfalipoic acid on MTX-induced damages. So, PubMed, Google or Web of Science were scanned to document the research of the protective effect of alfalipoic acid on MTX-induced damages from 2008 to 2018. Key words including Alfa lipoic acid, lipoic acid and methotrexate were searched