Thymosin beta-4 A/T polymorphism and acute coronary syndrome risk

Aim: Acute coronary syndrome (ACS) describes all the clinical conditions due to myocardial infarction that is caused by decreased blood flow in the coronary artery. Thymosin beta-4 (Tβ4) plays a significant role in the recovery of damaged tissues and promoting the survival of cardiomyocytes in ACS. In this study, it was aimed to determine the Tβ4 A/T (rs75112573) variation in ACS and its effects on the disease. Methods: This was a prospective case-control study. Forty-eight patients with ACS and 45 healthy controls were recruited for this study. Genetic analysis was performed using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP). Results: The AT genotype (p<0.001, X2:12.40, OR:5.42, 95% CI:2.02-14.53) and the A allele (p<0.001, X2:17.22, OR:6.66, 95% CI:2.61-16.98) frequency was found significantly higher in the patient group, while in the control group the TT genotype was statistically higher (p<0.001, X2:17.22, OR:2.13, 95% CI:1.44-3.16). LDL-cholesterol levels in the patient group (p<0.001, 95% CI:30.12-55.90), and HDL-cholesterol levels in the control group (p<0.001, 95% CI:5.30-15.34) were significantly higher. In the patient group, total cholesterol and HDL-cholesterol levels were found significantly higher in AT genotype carriers compared to the AA genotype carriers (p=0.036, 95% CI:0.59-17.25), while VLDL-cholesterol levels were higher in the AA genotype carriers compared to the AT (p=0.011, 95% CI:6.73-49.86), and TT (p=0.018, 95% CI:4.95-49.49) genotype carriers. Conclusion: It can be concluded that carrying the Tβ4 A/T (rs75112573) gene polymorphism AT genotype and the A allele may increase risk of ACS