Eff？cacy of Subcutaneous Methotrexate in Symmetr？cal Psor？at？c Plauqes

Abstract Introduction: Psoriasis is a chronic and recurrent skindisease characterized by inflammation and hyperproliferation, the etiology of which is unknown. Generally; In caseswhere more than 10% of body surface area is affected or not responding sufficiently with local treatments, systemic treatment agents are applied. Methotrexate is the most com-monly used systemic agent in the treatment of psoriasis. Aim: In our study, we aimed to evaluate the effectiveness of methotrexate applied SK in the symmetrically lo-cated psoriasis lesions, the response of the applied bodyside and under the applied lesion to the symmetry side andlesion. Materials and Methods: 22 psoriasis patients (15 E,7 K) who presented with symmetric plaque type psoriasislesions were included in the study. Patients received subcutaneous methotrexate treatment at a dose of 20 mg / weekfor a total of 8 weeks. The applied side of the body and theother side; The ’psoriasis field intensity score (PASI) before and after treatment was calculated and recorded. Results: When PASI scores were examined, it was10.98 pretreatment (PASI 1), 2.36 after the treatment andthe body side (PASI 2) at the symmetry of the body (PASI2) before the treatment and 10.66 after the treatment, and 2.68 after the treatment. There was a statistically signifi-cant decrease in PASI score before the treatment in bothgroups (p <0.0001). The mean decrease in PASI 1 was71.79% and PASI 2 was 66.90%. There was a statistically significant difference between PASI scores before and after treatment (p <0.0001). Conclusion: In conclusion, in the presence of systemictreatment resistant plaques, we believe that application ofSC methotrexate may be one of the primary steps in the treatment, and that application of the application under resistant lesions will increase the response to treatment and further studies should be performed in this respect