Mean Platelet Volumes Of Infants W？th Acute Bronch？ol？t？s, is There a Correlation Between Them?

Acute bronchiolitis is the most common lower respiratory tract infection of children younger than 2 years of age. Although the diagnose is clinical and the severity plays an important role in treatment, there aren't any standardized diagnostic criterias and severity assessment classifications for acute bronchiolitis available in literature. Results of the recent studies suggest that one of the platelet activation indice, MPV, can be used as an acute phase reactant in diseases. MPV has shown to be effected in local inflammations and to our knowledge there's only one recent study in children with acute bronchiolitis that demonstrates a decrease in MPV. Therefore more studies are needed to clarify the relation between MPV and acute bronchiolitis. In this present study we aim to determine the association between MPV and acute bronchiolitis, also identify whether it’s a useful marker on assessing disease severity or not. In this retrospective study we enrolled 555 children diagnosed with Acute bronchiolitis and 516 healthy infants with a matching age and sex. MPV levels were found significantly higher in patient group (8,2 ± 0,8 fL) than the control group (7,9 ± 0,8 fL). In terms of hospitalization need no significant difference detected between the MPV values of hospitalized group and outpatients, 8,3±0,8 fL; 8,2±0.7 fL respectively. In conclusion, our data show that MPV values significantly elevate in acute bronchiolitis compared to healthy infants. However, MPV can't be used as a guidance in attack severity nor can predict hospitalization, PICU admittion, and systemic steroid need