全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

基于近红外光谱结合化学计量学的板蓝根中浸出物含量的检测研究
Rapid Determination of Active Components Inradix Isatidis Based on Near Infrared Spectroscopy and Chemometrics

DOI: 10.12677/OE.2021.112008, PP. 63-68

Keywords: 小儿感冒颗粒,板蓝根,近红外光谱技术,偏最小二乘法,过程质量控制
Children Cold Granules
, Radix Isatidis, Near Infrared Spectroscopy, Partial Least Squares Method, Process Quality Control

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的本研究旨在建立近红外光谱法快速检测小儿感冒颗粒中重要药材板蓝根的浸出物含量的方法。方法利用近红外光谱仪对粉碎后的板蓝根药材样品进行扫描,对其光谱进行预处理和波段选择,并结合偏最小二乘法(partial least squares, PLS)建立浸出物含量快速无损检测方法。结果所建立的模型的决定系数R为0.9929,交叉验证均方根差值为0.735,对验证集样品进行预测并统计分析,预测值与真实值之间无显著差异(P > 0.05)。结论所建立的模型准确度高,适用于板蓝根药材粉末的浸出物含量的快速检测。
To establish a method for rapid determination of the extract content of Radix Isatidis in children’s ganomu granules by near infrared spectroscopy. Methods: Near-infrared spectroscopy (NIR) was used to scan the crushed samples of Radix isatidis. The spectra of the samples were pretreated and the bands were selected. A fast and nondestructive method for the extraction content was established by using partial least squares (PLS). Results: The determination coefficient R of the established model was 0.9929, and the root mean square difference of cross-validation was 0.735. The samples of the validation set were predicted and statistically analyzed, and there was no significant difference between the predicted value and the true value (P > 0.05). Conclusion: The established model has high accuracy and is suitable for the rapid determination of the extract content of Radix Isatidis.

References

[1]  国家药典委员会. 中国药典[M]. 北京: 中国医药科技出版社, 2020: 27.
[2]  徐丽华, 曹芳, 陈婷, 等. 板蓝根中的抗病毒活性成分[J]. 中国天然药物, 2005, 3(6): 359-360.
[3]  黄芳, 熊雅婷, 徐丽华, 等. 板蓝根不同提取物中抗病毒成分表告依春在大鼠体内的药代动力学[J]. 中国药科大学学报, 2006, 37(6): 519-522.
[4]  李闻文, 施凯. 板兰根、喜树果抗HFRSV和HSV-2作用的实验研究[J]. 湖南医科大学学报, 1994(4): 309-311.
[5]  方建国, 汤杰, 杨占秋, 等. 板蓝根体外抗单纯疱疹病毒Ⅰ型作用[J]. 中草药, 2005, 36(2): 242-244.
[6]  孙广莲, 胡志力, 孟红, 等. MTT法检测板蓝根抗巨细胞毒效应[J]. 山东中医药大学学报, 2000, 24(2): 137-138.
[7]  蒋锡源, 杨珍珠, 胡志军. 50种治疗肝炎中草药与制剂体外抑制HBAg活性的比较[J]. 现代应用药学, 1992(5): 208-211.
[8]  黄文玉, 唐敏, 王书珍, 等. 27种清热解毒中药对葡萄球菌耐药菌株的实验研究[J]. 山东中医杂志, 1991, 10(3): 40-41.
[9]  刘云海, 秦国伟, 寿建国, 等. 板蓝根抗内毒素活性化学成分的筛选[J]. 医药导报, 2002, 21(2): 74-75.
[10]  侯琦, 程桂芳, 张成义, 等. 4种刺激剂及抗炎药对HL-60细胞生成IL-8的影响[J]. 药学学报, 2000(3): 173-176.
[11]  梁永红, 侯华新, 黎丹戎, 等. 板蓝根二酮体b体外抗癌活性研究[J]. 中草药, 2000, 31(17): 531 -533.
[12]  侯华新, 蒙丹戎, 秦筲, 等. 板蓝根高级不饱和脂肪组酸体内抗肿瘤实验研究[J]. 中国新药与临床药理, 2002, 13(3): 156-158.
[13]  许益民, 陆平成, 王永珍, 等. 板蓝根多糖促进免疫功能的实验研究[J]. 中西医结合杂志, 1991(6): 357-359, 325-326.
[14]  秦箐, 贺海平, Soren, B.C., Hasse, B.R., Arsalan, K., 陈鸣. 板蓝根低极性流分的分离及其免疫活性[J]. 中国临床药学杂志, 2001(1): 29-31.

Full-Text

Contact Us

[email protected]

QQ:3279437679

WhatsApp +8615387084133