Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in H9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: Yang versus Yin
In the present study, two cell-based systems for assessing Yang and Yin
activities were for the first time used to investigate the effect of ursolic
acid (UA) and oleanolic acid (OA). The results indicated that while UA was only
active in the Yang assay, OA produced activity in the Yin assay. The Yang/Yin
activity of UA/OA may be attributed to their distinct molecular structures,
which confer their differential ability to interact with mitochondrial membrane
or cellular membrane lipids, with resultant membrane fluidization and
potentiation of biological responses.
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