Male Breast Cancer (MBC) has a familial component
thus identification of polymorphic risk alleles of candidate genes and/or
cytogenetic anomalies may help to predict the risk for the offspring of MBC
patients. The conventional metaphase cytogenetics can indicate loci that are
hotspots while analysis by single nucleotide polymorphism arrays (SNP-A) can
identify chromosomal defects which may play
a role in the etiology of cancer. A cumulative genotype risk due to each
allele of candidate genes of the signaling pathways regulating c-MYC, HIF1A, TP53and BRCA1may be a factor facilitating
cancer development. Cancer risk was assessed
in a 35-year-old healthy son of a 60-year-old MBC patient with a family history of cancer by metaphase cytogenetics, SNP-A and analysis of 25 polymorphisms in six
genesTP53, MDM2, VEGF, VEGFR1, HIF1A, and BRCA1. The risk genotype GG-TT of MDM2 309T > G and
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