全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Stroke and HIV: Correlation between Viral Load and Type of Stroke

DOI: 10.4236/nm.2021.124012, PP. 163-167

Keywords: Viral Load, HIV, Stroke

Full-Text   Cite this paper   Add to My Lib

Abstract:

Introduction: The role of immunosuppression of TCD4+ lymphocytes in the onset of stroke in people living with HIV has been reported in numerous studies examining the co-morbidity of stroke and HIV. Objective: To determine the correlation between the viral load and the type of stroke. Methodology: This was a 7-month cross-sectional descriptive study carried out in the Neurology Department of Loandjili General Hospital in Pointe-Noire. The study population consisted of patients living with HIV who had a stroke confirmed by brain scan. The sero-immunological investigation consisted of looking for T lymphocyte typing from two kits: a CD4+ T lymphocyte typing reagent kit (BD FACS Presto TM) and a GeneXpert kit for viral load (Xpert®HIV-1 Viral Load). The database was made from the 2010 version of Microsoft Excel. Results: We included 16 patients living with HIV, 56% of whom were women with a sex ration of 0.78. The mean age was 56.92 ± 11.21. The mean number of TCD4+ lymphocytes was 413.44 ± 677.95/mm3; minimum: 93/mm3; maximum: 2854/mm3. The mean viral load was 17,996.31 ± 20,982.22/mm3; minimum: 1002/mm3; maximum: 67,229/mm3. No significant difference between the viral load and the occurrence of the stroke (p = 0.13). Conclusion: Our study did not show a causal link between viral load, immunosuppression of TCD4+ lymphocytes and the onset of stroke.

References

[1]  Mapoure Njankouo, Y., Nepetsoun Nkongnin, I., Namme Luma, H., Mbatachou Ngahane, B.H., Barla, E., et al. (2016) Incidence des AVC chez les patients VIH+ sous TAR au long court. The Pan African Medical Journal, 24, Article No. 45.
[2]  Koumeka (2015) Risque d’accident vasculaire cérébral chez les personnes vivant avec le VIH, admis à l’Hôpital général de Loandjili: Etude des facteurs de risque. Thèse de Médecine, Université Marien Ngouabi de Brazzaville (FSSA), Congo.
[3]  Sen, S., Rabinstein, A.A., Elkind, M.S.V. and Powers, W.J. (2012) Recent Developments Regarding Human Immunodeficiency Virus Infection and Stroke. Cerebrovascular Diseases, 33, 209-218. https://doi.org/10.1159/000335300
[4]  Tipping, B., De Villiers, L., Wainwright, H., Candy, S. and Bryer, A. (2007) Stroke in Patients with Human Immunodeficiency virus Infection. Journal of Neurology, Neurosurgery and Psychiatry, 78, 1320-1324.
https://doi.org/10.1136/jnnp.2007.116103
[5]  Gnonlonfoun, D., Adjien-Kodjo, C., Adoukonou, T.A., Ossou-Nguiet, P.M., Mapoure, Y., Zannout, H., et al. (2013) L’infection à virus de l’immunodéficience humaine (VIH), facteur prédictif de gravité et de mortalité des accidents vasculaires cérébraux au Centre National Hospitalier et Universitaire HUBERT KOUTOUKOU MAGA (CNHU-HKM) de Cotonou, Bénin. African Journal of Neurological Sciences, 32, 14-23.
[6]  Balogou, A.A.K., Grunitzky, E.K., Assogba, K., Apetse, K., Kombate, D. and Amouzouvi, D. (2008) Accidents vasculaires cérébraux chez le sujet jeune (15 à 45 ans) dans le service de neurologie du CHU Campus de Lomé. African Journal of Neurological Sciences, 27, 44-51.
[7]  Artzen, M., Jubt, F., Evers, S., Volker, H., Fiori, W., Reichelt, D., et al. (2014) Cerebrovascular events in HIV-infected patients: an analysis of a cohort of 3203 HIV+ patients during the times of cART. International Journal of Neuroscience, 125, 601-611. https://doi.org/10.3109/00207454.2014.956870
[8]  Morlat, P. (2013) Prise en charge médicale des personnes vivantes avec le VIH. Recommandations du groupe d’experts CNS et ANRS, France.
[9]  Ossou-Nguiet, P.M., Gombet, T., Ossil-Ampion, M., Ellenga Mbolla, F.B., Otiabanda, G.F., Mahoungou-Nguimbi, K.C., et al. (2013) Facteurs de mortalité des accidents vasculaires cérébraux au CHU de Brazzaville. Revue Africaine d’Anesthésiologie et de Médecine d’Urgence, 18, 15-19. https://doi.org/10.1016/j.respe.2013.09.004
[10]  Durand, M., Sheehy, O., Baril, J.G., Lelorier, J. and Tremblay, C.L. (2013) Risk of Spontaneaous Intracranial Hemorrhage in HIV-Infected Individuals: A Population-Based Cohort Study. Journal of Stroke and Cerebrovascular Diseases, 22, e34-e41.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.03.014
[11]  Heikinheimo, T., Chimbayo, D., Kumwenda, J.J., Kampondeni, S. and Allain, T.J. (2012) Stroke Outcomes in Malawi, a Country with High Prevalence of HIV: A Prospective Follow-Up Study. PLoS ONE, 7, e33765.
https://doi.org/10.1371/journal.pone.0033765
[12]  Chow, F.C., Regan, S., Feske, S., Meigs, J.B., Grinspoon, S.K. and Triant, V.A. (2012) Comparison of Ischemic Stroke Incidence in HIV-Infected and Non-HIV-Infected Patients in a U.S. Health Care System. Journal of Acquired Immune Deficiency Syndromes, 60, 351-358.
[13]  Dobbs, M.R. and Berger, J.R. (2009) Stroke in HIV infection and AIDS. Expert Review of Cardiovascular Therapy, 7, 1263-1271. https://doi.org/10.1586/erc.09.72
[14]  Ortiz, G., Koch, S., Romano, J.G., Forteza, A.M. and Rabinstein, A.A. (2007) Mechanisms of Ischemic Stroke in HIV-Infected Patients. Neurology, 68, 1257-1261.
https://doi.org/10.1212/01.wnl.0000259515.45579.1e
[15]  Mochan, A., Modi, M. and Modi, G. (2003) Stroke in Black South African HIV-Positive Patients: A Prospective Analysis. Strock, 34, 10-15.
https://doi.org/10.1161/01.STR.0000043821.35051.FA

Full-Text

Contact Us

[email protected]

QQ:3279437679

WhatsApp +8615387084133