Objective: To determine the role of CD4+ and CD8+ T
lymphocytes in the onset of stroke in people living with HIV. Methodology: This was a descriptive, cross-sectional study from January to July 2019, in the
neurology department of loandjili general hospital, including any patient
hospitalized for a first episode of stroke confirmed by brain scan. The study
variables were: age, sex, CRP value, serum T cell CD4+, CD8+. The statistical
analysis was carried out using the EPI info 7 software. Results: Twenty
stroke patients were included. The relative frequency of HIV was 20%. The risk
factors were potentiated by immunosuppression
of CD4+ T cells. Sixty percent (60%) of the patients had a CD4+ count <
200/mm3 and the mean CD4+ count was±191/mm3. Stroke was the predominant mechanism of injury with
a frequency of 70%, the only injury mechanism of stroke in patients with
CD8+ T cell count > 800/mm3 (p = 0.04). Conclusion: Risk factors
are potentiated by TCD4+ lymphocyte immunosupression, also CD8+ lymphocytes of
immune system activation marker are a cardiovascular
risk factor for living people with HIV.
References
[1]
ONUSIDA/OMS (2015) Rapport Annuel 2014. https://www.unaids.org
[2]
Gombet, T., Ellenga Mbolla, B.F., Ikama, M.S. and Etitiele, F. (2007) Facteurs de risque des accidents vasculaires ischémiques au centre hospitalier et universitaire de Brazzaville. Médecine d’Afrique Noire, 54, 640-645.
[3]
Ossou-Nguiet, P.M., Gombet, T., Ossil-Ampion, M., Ellenga Mbolla, B.F., Otiabanda, G.F., Mahoungou-Nguimbi, K.C., et al. (2013) Facteurs de mortalité des accidents vasculaires cérébraux au CHU de Brazzaville. RAMUR, 18, 15-19.
[4]
Sen, S., Rabinstein, A.A., Elkind, M.S.V. and Powers, W.J. (2012) Recent Developments Regarding Human Immunodeficiency Virus Infection and Stroke. Cerebrovascular Diseases, 33, 209-218. https://doi.org/10.1159/000335300
[5]
Qureshi, A.I., Janssen, R.S. and Karon, J.M. (1997) Human Immunodeficiency Virus Infection and Stroke in Young Patients. Archives of Neurology, 54, 1150-1153. https://doi.org/10.1001/archneur.1997.00550210078016
[6]
Gnonlonfoun, D., Adjien-Kodjo, C., Adoukonou, T.A., Ossou-Nguiet, P.M., Mapoure, Y., Zannout, H., et al. (2013) L’infection à virus de l’immunodéficience humaine (VIH), facteur prédictif de gravité et de mortalité des accidents vasculaires cérébraux au Centre National Hospitalier et Universitaire-Hubert Koutoukou Maga (CNHU-HKM) de Cotonou, Bénin. African Journal of Neurological Sciences, 32, 14-23.
[7]
Heikinheimo, T., Chimbayo, D., Kumwenda, J.J., Kampondeni, S. and Allain, T.J. (2012) Stroke Outcomes in Malawi, a Country with High Prevalence of HIV: A Prospective Follow-Up Study. PLoS ONE, 7, e33765. https://doi.org/10.1371/journal.pone.0033765
[8]
Leys, D., Lucas, C., Gautier, C., Hachulla, E. and Pruvo, J.P. (2004) Accidents ischémiques cérébraux du sujet jeune. EMC-Neurologie, 1, 375-389. https://doi.org/10.1016/j.emcn.2004.06.002
[9]
Longo-Mbenza, B., Longokolo Mashi, M., Lelo Tshikwela, M., Mokondjimobe, E., Gombet, T., Ellenga-Mbolla, B., et al. (2011) Relationship between Younger Age, Autoimmunity, Cardiometabolic Risk, Oxidative Stress, HAART, and Ischemic Stroke in Africans with HIV/AIDS. International Scholarly Research Notices, 2011, Article ID: 897908. https://doi.org/10.5402/2011/897908
[10]
Marcus, J.L., Leyden, W.A., Chao, C.R., Chow, F.C., Horberg, M.A., Hurley, L.B., et al. (2014) HIV Infection and Incidence of Ischemic Stroke. AIDS, 28, 1911-1919. https://doi.org/10.1097/QAD.0000000000000352
[11]
Krikke, M., Van Lelyveld, S.F.L., Tesselaar, K., Arend, J.E., Hoepelman, I.M. and Visseren, F.L.J. (2014) The Role of T Cells in the Development of Cardiovascular Disease in HIV-Infected Patients. Atheroslerosis, 237, 92-98.
[12]
Assalum, H., Alkayem, M. and Shabareck, N. (2013) HIV Infection and Acute Stroke: Report and a Review of the Literature. Case Report in Medicine, 2013, Article ID: 892054. https://doi.org/10.1155/2013/892054
[13]
Ortiz, G., Koch, S., Romano, J.G., Forteza, A.M. and Rabinstein, A.A. (2007) Mechanisms of Ischemic Stroke in HIV-Infected Patients. Neurology, 68, 1257-1261. https://doi.org/10.1212/01.wnl.0000259515.45579.1e
[14]
Tipping, B., De Villiers, L., Wainwright, H., Candy, S. and Bryer, A. (2007) Stroke in Patients with Human Immunodeficiency Virus Infection. Journal of Neurology, Neurosurgery and Psychiatry, 78, 1320-1324. https://doi.org/10.1136/jnnp.2007.116103
[15]
Benjamin, L.A., Bryer, A., Emsley, H.C.A., Khoo, S., Solomon, T. and Connor, M.D. HIV Infection and Stroke: Current Perspectives and Futures Directions. The Lancet Neurology, 11, 878-890. https://doi.org/10.1016/S1474-4422(12)70205-3
