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邻硝基苯甲醛的制备与谱学分析
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Abstract:
邻硝基苯甲醛是重要的有机中间体，在有机合成和制药方面有着广泛的应用，本文首先合成N,N’-二甲基甲酰胺二甲基缩醛(DMFDMA)，采用邻硝基甲苯与DMFDMA经缩合氧化合成邻硝基苯甲醛，并通过1H NMR、13C NMR、FT-IR等谱学手段对产物进行分析，总收率为88.03%、纯度高达99.07% (HPLC)。本合成生产工艺方法经济成本低，收率高，对环境污染小，相较于传统工艺有较为明显的优势。
2-Nnitrobenzaldehyde is an important organic intermediate, which is widely used in organic syn-thesis and pharmaceutical fields. 2-Nitrobenzaldehyde was synthesized from N,N’-dimethylformamide dimethyl acetal (DMFDMA) by condensation oxidation. The isolated prod-uct was analyzed by 1H NMR, 13C NMR and FT-IR spectroscopic methods. The total yield was 88.03%, and the purity was as high as 99.07% (HPLC). The synthetic production process has the advantages of low economic cost, high yield and low environmental pollution, and has obvious advantages over the traditional process.
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