Setting: Four
decentralised sites are located in rural areas and
one centralised hospital in KwaZulu-Natal province, South Africa. Objective:To analyse riskfactors associated with multidrug-resistant
tuberculosis (MDR-TB) using competing risks analysis. Understanding
factors associated with MDR-TB and obtaining valid parameter estimates could
help in designing control and intervention strategies to lower TB mortality. Method: A prospective study was performed using a competing risk analysis in patients
receiving treatment for MDR-TB. The study focused on 1542 patients (aged 18
years and older) who were diagnosed of MDR-TB between July 2008 and June 2010.
Time to cure MDR-TB was used as the dependent variable and time to death was
the competing risk event. Results: The Fine-Gray regression model indicated that baseline
weight was highly significant with sub-distribution hazard ration (SHR) = 1.02,
95% CI: 1.01 - 1.02. This means that weight gain in a month increased chances
of curing MDR-TB by 2%. Results show that lower chances to cure MDR-TB were among patients between 41 to 50 years compared to
those patients who were between 18 to 30
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