After
proving safety in animal and human models, a series of clinical trials were
conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan
on the immune system; and on self-perceived effects on subjects’ quality of
life (QoL) using a Visual Analogue Scale (VAS). In one study, a subject
population that was self-perceived to be fatigued was administered an
undetaured beta-glucan, to determine if this supplementation affected their
quality-of-life as a result of an increased immune system response. 44 subjects
were administered 1 mg/mL bid of the undenatured beta-glucan (Lentinex®) for
four weeks. Prior to the beginning of the administration, and following the four-week administration period, the subjects were asked to fill out a
quality-of-life VAS questionnaire. The changes in the two questionnaires
revealed differences that occurred as a result of the beta-glucan administration. More than 75% of the subjects scored “better” (more
than 1cm on the
VAS) with regard to feeling in a good mood, and feeling rested. More than 60%
increased their energy and reduced their tiredness and exhaustion, and 70% felt
less stressed. In a second study, subjects aged 40 years and older, believed to be in good general
health,seeking
therapy for tiredness/exhaustion/fatigue or similar conditions (neurasthenia) which were
administered 1 mg/mL bid Lentinex
References
[1]
Kristiansen, B. (2009) Immune Modulating Compounds from Fungi US 7,514,085 April 6, 2009.
[2]
Kristiansen, B. (2010) Immune Modulating Compounds from Fungi. US 7,682,615, March 23, 2010.
[3]
Gaullier, J.-M., Sleboda, J., Øfjord, E.S., et al. (2011) Supplementation with a Soluble Beta-Glucan Exported from Shiitake Medicinal Mushroom, Lentinus Edodes (Berk) Singer Mycelium: A Crossover, Placebo-Controlled Study in Healthy Elderly. International Journal of Medicinal Mushrooms, 13, 319-326.
https://doi.org/10.1615/IntJMedMushr.v13.i4.10
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Anna, C., Drywień, M.E., Hamulka, J. and Sadkowski, T. (2019) Nutraceutical Functions of Beta-Glucans in Human Nutrition. Roczniki Państwowego Zakladu Higieny [Annals of the National Institute of Hygiene], 7, 4.
[8]
Ayaka, N., Yamada, K., Iwata, O., et al. (2018) β-Glucan in Foods and Its Physiological Functions. Journal of Nutritional Science and Vitaminology (Tokyo), 64, 8-17. https://doi.org/10.3177/jnsv.64.8
[9]
Fjeldstad, B. (2008) Effect of Lentinex® in a “Fatigue” Population Visiting an Aroma Therapeutic Clinic: An Opinion Survey.
[10]
El Khoury, D., Cuda, C., Luhovyy, B.L. and Anderson, G.H. (2012) Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome. Journal of Nutrition and Metabolism, 2012, Article ID 851362. https://doi.org/10.1155/2012/851362
[11]
Fjord, E.S. (2008) Clinical Study Short Report on QoL Dose Escalation Safety Study of Lentinex® in Healthy Subjects: A Double Blind Placebo-Controlled Study, Bergen II, Centre for Clinical Trials (CENCLIN), Gamlehaugvei 20, N-5231 Paradis, Norway.