5-羟色胺在脂质代谢中的研究进展
Research Progresses for 5-Hydroxytryptamine in Lipid Metabolism

DOI: 10.12677/BP.2022.121001, PP. 1-9

Keywords: 血清素，脂质代谢，肥胖，能量稳态
Serotonin, Lipid Metabolism, Obesity, Energy Balance

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Abstract:

血清素，又称5-羟色胺(5-hydroxytryptamine, 5-HT)，是一种高度保守的生物胺，主要在胃肠道和中枢神经系统中高表达，可以结合7种不同受体家族的受体，参与机体众多的生理及病理过程。研究表明，血清素是能量摄入与消耗的主要调节剂，外周血清素通过上调脂质合成促进能量有效储存，进而诱发胰岛素抵抗、血脂异常、肝脂肪变性、凝血病和高血压等肥胖症的不利代谢后果，而中枢血清素可抑制食欲并通过驱动交感神经增加棕色脂肪组织的能量消耗。因此，5-HT在肥胖疾病中的作用备受关注。本文结合最新的研究进展对5-HT在脂质代谢中的作用进行简要归纳。
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a highly conserved biogenic amine that is highly expressed in the gastrointestinal tract and central nervous system. It participates in numerous physiological and pathological processes by binding to seven different receptor families. Serotonin has been shown it is the main regulator of energy intake and consumption. Peripheral serotonin promotes effective energy storage by up-regulating lipid synthesis, inducing adverse metabolic consequences, such as obesity, insulin resistance, dyslipidemia, hepatic steatosis, coagulopathy and hypertension. Central serotonin suppresses appetite and increases energy expenditure by increasing sympathetic drive to brown adipose tissue. Therefore, the role of 5-HT in obesity has attracted much attention. In this review, we highlight the most recent advances for the roles of 5-HT in lipid metabolism.

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