E-Cadherin的表达调控及对细胞增殖的影响
Regulation of E-Cadherin Expression and Effects on Cell Proliferation

DOI: 10.12677/BP.2022.121002, PP. 10-19

Keywords: E-Cadherin，CAT，细胞增殖，转录调控，癌症
E-Cadherin, CAT, Cell Proliferation, Transcriptional Regulation, Cancer

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Abstract:

E-钙粘蛋白(E-cadherin)主要在上皮细胞膜上表达，发挥细胞间粘附作用并抑制入侵，其在细胞增殖的过程中也扮演着重要角色，主要通过Wnt，Hippo信号通路及Rho家族的小GTPases影响上皮细胞的增殖。E-cadherin在细胞膜上的稳定性和准确的功能通过与连环蛋白(catenin, CAT)形成稳定的复合物来实现。E-cadherin功能缺失在癌症细胞中被发现，其表达失调主要发生在表观遗传学水平。E-cadherin表达水平下降与肿瘤的出现、分化、侵入和运动转移等密切相关。本文主要介绍了E-cadherin对细胞增殖的影响，分析了其在肿瘤发生和发展过程中调节细胞增殖、侵袭和细胞内信号传导的一些分子机制。
E-cadherin is mainly expressed on epithelial cell membranes, plays an intercellular adhesion and inhibits invasion, which also plays an important role in cell proliferation, mainly affecting epithelial cell proliferation through Wnt, Hippo signaling pathways and small GTPases of the Rho family. The stability and accurate function of E-cadherin at the cell membrane is achieved by forming a stable complex with catenin (CAT). Loss of E-cadherin function has been found in cancer cells, and its dysregulation mainly occurs at the epigenetic level. The decreased expression level of E-cadherin is closely related to the emergence, differentiation, invasion and movement metastasis of tumors. This paper mainly introduces the effect of E-cadherin on cell proliferation and analyzes some of the molecular mechanisms by which it regulates cell proliferation, invasion and intracellular signaling during tumorigenesis and development.

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