The high
incidence of breast cancer poses one of the greatest risks to female health
worldwide. Sentinel lymph node biopsy (SLNB) is the standard of treatment for
patients with axillary lymph node-negative early-stage breast cancer. Herein,
the precise use of tracers is the key to ensuring the success of SLNB. However,
owing to select-few limitations of traditional tracers, their clinical application is limited. New tracer
techniques, such as the near-infrared fluorescent dye method (using
indocyanine green), contrast-enhanced ultrasound, and superparamagnetic iron
oxide nanoparticles are being applied in clinical practice. In this paper, we
review the recent progress in SLNB tracer technology.
References
[1]
Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. and Bray, F. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. https://doi.org/10.3322/caac.21660
[2]
Giuliano, A.E., Ballman, K.V., McCall, L., Beitsch, P.D., Brennan, M.B., Kelemen, P.R., Ollila, D.W., Hansen, N.M., Whitworth, P.W., Blumencranz, P.W., Leitch, A.M., Saha, S., Hunt, K.K. and Morrow, M. (2017) Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial. Journal of the American Medical Association, 318, 918-926.
https://doi.org/10.1001/jama.2017.11470
[3]
Mamounas, E.P., Kuehn, T., Rutgers, E.J.T. and von Minckwitz, G. (2017) Current Approach of the Axilla in Patients with Early-Stage Breast Cancer. The Lancet, S0140-6736, 31451-31454. https://doi.org/10.1016/S0140-6736(17)31451-4
[4]
Larson, K.E., Valente, S.A., Tu, C., Dalton, J. and Grobmyer, S.R. (2018) Surgeon-Associated Variation in Breast Cancer Staging with Sentinel Node Biopsy. Surgery, 164, 680-686. https://doi.org/10.1016/j.surg.2018.06.021
[5]
Gradishar, W.J., Anderson, B.O., Abraham, J., Aft, R., Agnese, D., Allison, K.H., Blair, S.L., Burstein, H.J., Dang, C., Elias, A.D., Giordano, S.H., Goetz, M.P., Goldstein, L.J., Isakoff, S.J., Krishnamurthy, J., Lyons, J., Marcom, P.K., Matro, J., Mayer, I.A., Moran, M.S., Mortimer, J., O’Regan, R.M., Patel, S.A., Pierce, L.J., Rugo, H.S., Sitapati, A., Smith, K.L., Smith, M.L., Soliman, H., Stringer-Reasor, E.M., Telli, M.L., Ward, J.H., Young, J.S., Burns, J.L. and Kumar, R. (2020) Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network, 18, 452-478.
https://doi.org/10.6004/jnccn.2020.0016
[6]
Chinese Anti-Cancer Association Breast Cancer Professional Committee (2021) Chinese Anti-Cancer Association Breast Cancer Diagnosis and Treatment Guidelines and Specifications (2021 Edition). China Cancer Journal, 31, 954-1040.
https://doi.org/10.19401/j.cnki. 1007-3639.2021.10.013
[7]
Taruno, K., Kurita, T., Kuwahata, A., Yanagihara, K., Enokido, K., Katayose, Y., Nakamura, S., Takei, H., Sekino, M. and Kusakabe, M. (2019) Multicenter Clinical Trial on Sentinel Lymph Node Biopsy Using Superparamagnetic Iron Oxide Nanoparticles and a Novel Handheld Magnetic Probe. Journal of Surgical Oncology, 120, 1391-1396. https://doi.org/10.1002/jso.25747
[8]
Jakobsen, J.K. (2021) Sentinel Node Methods in Penile Cancer—A Historical Perspective on Development of Modern Concepts. Seminars in Nuclear Medicine, in Press. https://doi.org/10.1053/j.semnuclmed.2021.11.010
[9]
Li, J., Lu, M., Cheng, X., Hu, Z., Li, H., Wang, H., Jiang, J., Li, T., Zhang, Z., Zhao, C., Ma, Y., Tan, B., Liu, J. and Yu, Y. (2019) How Pre-Operative Sentinel Lymph Node Contrast-Enhanced Ultrasound Helps Intra-operative Sentinel Lymph Node Biopsy in Breast Cancer: Initial Experience. Ultrasound in Medicine & Biology, 45, 1865-1873. https://doi.org/10.1016/j.ultrasmedbio.2019.04.006
[10]
Bevers, T.B., Helvie, M., Bonaccio, E., Calhoun, K.E., Daly, M.B., Farrar, W.B., Garber, J.E., Gray, R., Greenberg, C.C., Greenup, R., Hansen, N.M., Harris, R.E., Heerdt, A.S., Helsten, T., Hodgkiss, L., Hoyt, T.L., Huff, J.G., Jacobs, L., Lehman, C.D., Monsees, B., Niell, B.L., Parker, C.C., Pearlman, M., Philpotts, L., Shepardson, L.B., Smith, M.L., Stein, M., Tumyan, L., Williams, C., Bergman, M.A. and Kumar, R. (2018) Breast Cancer Screening and Diagnosis, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network, 16, 1362-1389. https://doi.org/10.6004/jnccn.2018.0083
[11]
Krag, D.N., Anderson, S.J., Julian, T.B., Brown, A.M., Harlow, S.P., Ashikaga, T., Weaver, D.L., Miller, B.J., Jalovec, L.M., Frazier, T.G., Noyes, R.D., Robidoux, A., Scarth, H.M., Mammolito, D.M., McCready, D.R., Mamounas, E.P., Costantino, J.P. and Wolmark, N. (2007) National Surgical Adjuvant Breast and Bowel Project. Technical Outcomes of Sentinel-Lymph-Node Resection and Conventional Axillary-Lymph-Node Dissection in Patients with Clinically Node-Negative Breast Cancer: Results from the NSABP B-32 Randomised Phase III Trial. The Lancet Oncology, 8, 881-888. https://doi.org/10.1016/S1470-2045(07)70278-4
[12]
Krag, D.N., Weaver, D.L., Alex, J.C. and Fairbank, J.T. (1993) Surgical Resection and Radiolocalization of the Sentinel Lymph Node in Breast Cancer Using a Gamma Probe. Surgical Oncology, 2, 335-340.
https://doi.org/10.1016/0960-7404(93)90064-6
[13]
Giuliano, A.E., Kirgan, D.M., Guenther, J.M. and Morton, D.L. (1994) Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer. Annals of Surgery, 220, 391-401. https://doi.org/10.1097/00000658-199409000-00015
[14]
Radl, B. and Mlineritsch, B. (2017) ASCO 2017-Highlights of Gynecological Cancer. Memo—Magazine of European Medical Oncology, 10, 237-239.
https://doi.org/10.1007/s12254-017-0371-z
[15]
Nandu, V.V. and Chaudhari, M.S. (2017) Efficacy of Sentinel Lymph Node Biopsy in Detecting Axillary Metastasis in Breast Cancer Using Methylene Blue. Indian Journal of Surgical Oncology, 8, 109-112.
https://doi.org/10.1007/s13193-016-0616-z
[16]
Mok, C.W., Tan, S.M., Zheng, Q. and Shi, L. (2019) Network Meta-Analysis of Novel and Conventional Sentinel Lymph Node Biopsy Techniques in Breast Cancer. BJS Open, 3, 445-452. https://doi.org/10.1002/bjs5.50157
[17]
Valente, S.A., Al-Hilli, Z., Radford, D.M., Yanda, C., Tu, C. and Grobmyer, S.R. (2019) Near Infrared Fluorescent Lymph Node Mapping with Indocyanine Green in Breast Cancer Patients: A Prospective Trial. Journal of the American College of Surgeons, 228, 672-678.
[18]
Somashekhar, S.P., Kumar, C.R., Ashwin, K.R., Zaveri, S.S., Jampani, A., Ramya, Y., Parameswaran, R. and Rakshit, S. (2020) Can Low-Cost Indo Cyanine Green Florescence Technique for Sentinel Lymph Node Biopsy Replace Dual Dye (Radio-Colloid and Blue Dye) Technique in Early Breast Cancer: A Prospective Two-Arm Comparative Study. Clinical Breast Cancer, 20, E576-E583.
https://doi.org/10.1016/j.clbc.2020.03.013
[19]
Motomura, K., Inaji, H., Komoike, Y., Kasugai, T., Noguchi, S. and Koyama, H. (1999) Sentinel Node Biopsy Guided by Indocyanine Green Dye in Breast Cancer Patients. Japanese Journal of Clinical Oncology, 29, 604-607.
https://doi.org/10.1093/jjco/29.12.604
[20]
Jeremiasse, B., van den Bosch, C.H., Wijnen, M.W.H.A., Terwisscha van Scheltinga, C.E.J., Fiocco, M.F. and van der Steeg, A.F.W. (2020) Systematic Review and Meta-Analysis Concerning Near-Infrared Imaging with Fluorescent Agents to Identify the Sentinel Lymph Node in Oncology Patients. European Journal of Surgical Oncology, 46, 2011-2022. https://doi.org/10.1016/j.ejso.2020.07.012
[21]
Wang, Z., Yang, X., Wang, J., Liu, P., Pan, Y., Han, C. and Pei, J. (2021) Real-Time in Situ Navigation System with Indocyanine Green Fluorescence for Sentinel Lymph Node Biopsy in Patients with Breast Cancer. Frontiers in Oncology, 11, Article ID: 621914. https://doi.org/10.3389/fonc.2021.621914
[22]
Wu, G.H., Zhang, H.X., Wang, M.H. and Hu, D.W. (2016) Clinical Study of the Effect of Fluorescence and Blue Staining on Sentinel Lymph Node Biopsy in Breast Cancer. Chinese Journal of General Surgery, 31, 68-69
[23]
Niu, M.Y., Yang, C.X., Xing, Y., Zhang, L., Wu, J. and Hu, D.W. (2020) Long Term Follow-Up Results and Prognostic Analysis of Double Tracer in Sentinel Lymph Node Biopsy for Early Breast Cancer. Chinese Journal of Physicians, 22, 1511-1515.
[24]
Goonawardena, J., Yong, C. and Law, M. (2020) Use of Indocyanine Green Fluorescence Compared to Radioisotope for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: Systematic Review and Meta-Analysis. The American Journal of Surgery, 220, 665-676. https://doi.org/10.1016/j.amjsurg.2020.02.001
[25]
Ngô, C., Sharifzadehgan, S., Lecurieux-Lafayette, C., Belhouari, H., Rousseau, D., Bonsang-Kitzis, H., Crouillebois, L., Balaya, V., Oudard, S., Lécuru, F. and Elaidi, R.T. (2020) Indocyanine Green for Sentinel Lymph Node Detection in Early Breast Cancer: Prospective Evaluation of Detection Rate and Toxicity—The FLUOBREAST Trial. The Breast Journal, 26, 2357-2363. https://doi.org/10.1111/tbj.14100
[26]
Thomas, P., Evi, J., Anton, S., et al. (2018) Sentinel Lymph Node Biopsy in Breast Cancer Patients by Means of Indocyanine Green Using the Karl Storz VITOM Fluorescence Camera. BioMed Research International, 2018, Article ID: 6251468.
[27]
Xiong, L., Gazyakan, E., Yang, W., Engel, H., Hünerbein, M., Kneser, U. and Hirche, C. (2014) Indocyanine Green Fluorescence-Guided Sentinel Node Biopsy: A Meta-Analysis on Detection Rate and Diagnostic Performance. European Journal of Surgical Oncology, 40, 843-849. https://doi.org/10.1016/j.ejso.2014.02.228
[28]
Cong, B.B., Sun, X., Song, X.R., Liu, Y.B., Zhao, T., Cao, X.S., Qiu, P.F., Tian, C.L., Yu, J.M. and Wang, Y.S. (2016) Preparation Study of Indocyanine Green-Rituximab: A New Receptor-Targeted Tracer for Sentinel Lymph Node in Breast Cancer. Oncotarget, 7, 47526-47535. https://doi.org/10.18632/oncotarget.10204
[29]
Zhang, C., Li, Y., Wang, X., Zhang, M., Jiang, W. and Ou, J. (2021) Clinical Study of Combined Application of Indocyanine Green and Methylene Blue for Sentinel Lymph Node Biopsy in Breast Cancer. Medicine, 100, e25365.
https://doi.org/10.1097/MD.0000000000025365
[30]
Zheng, J., Ren, W., Chen, T., Jin, Y., Li, A., Yan, K., Wu, Y. and Wu, A. (2018) Recent Advances in Superparamagnetic Iron Oxide Based Nanoprobes as Multifunctional Theranostic Agents for Breast Cancer Imaging and Therapy. Current Medicinal Chemistry, 25, 3001-3016. https://doi.org/10.2174/0929867324666170705144642
[31]
Alvarado, M.D., Mittendorf, E.A., Teshome, M., Thompson, A.M., Bold, R.J., Gittleman, M.A., Beitsch, P.D., Blair, S.L., Kivilaid, K., Harmer, Q.J. and Hunt, K.K. (2019) SentimagIC: A Non-Inferiority Trial Comparing Superparamagnetic Iron Oxide versus Technetium-99m and Blue Dye in the Detection of Axillary Sentinel Nodes in Patients with Early-Stage Breast Cancer. Annals of Surgical Oncology, 26, 3510-3516. https://doi.org/10.1245/s10434-019-07577-4
[32]
Bazire, L., Alran, S., El Bamrani, S., Gaujal, L., Vincent-Salomon, A., Tardivon, A. and Kirova, Y.M. (2019) Radiation Therapy after Sentinel Lymph Node Biopsy for Early Stage Breast Cancer Using a Magnetic Tracer: Results of a Single Institutional Prospective Study of Tolerance. Cancer/Radiothérapie, 23, 23-27.
https://doi.org/10.1016/j.canrad.2018.03.008
[33]
Ghilli, M., Carretta, E., Di Filippo, F., Battaglia, C., Fustaino, L., Galanou, I., Di Filippo, S., Rucci, P., Fantini, M.P. and Roncella, M. (2017) The Superparamagnetic Iron Oxide Tracer: A Valid Alternative in Sentinel Node Biopsy for Breast Cancer Treatment. European Journal of Cancer Care, 26, e12385.
https://doi.org/10.1111/ecc.12385
[34]
Zhao, J., Zhang, J., Zhu, Q.L., Jiang, Y.X., Sun, Q., Zhou, Y.D., Wang, M.Q., Meng, Z.L. and Mao, X.X. (2018) The Value of Contrast-Enhanced Ultrasound for Sentinel lymph Node Identification and Characterisation in Pre-Operative Breast Cancer Patients: A Prospective Study. European Radiology, 28, 1654-1661.
https://doi.org/10.1007/s00330-017-5089-0
[35]
Liu, J., Liu, X., He, J., Gou, B., Luo, Y., Deng, S., Wen, H. and Zhou, L. (2019) Percutaneous Contrast-Enhanced Ultrasound for Localization and Diagnosis of Sentinel Lymph Node in Early Breast Cancer. Scientific Reports, 9, Article No. 13545.
https://doi.org/10.1038/s41598-019-49736-3
