This paper aims to examine theories that attempt to
explain biochemical changes in the brain as well as the metabolism of
individuals who experience symptoms and conditions related to neurological
disorders like depression. A systematic literature search was performed on NCBI
and PubMed. The search included the keywords neurological disorders, monoamine
hypothesis, metabolic syndrome, oxytocin receptor, dietary health, and
magnesium intake. Twenty-five research articles met the criteria for the
literature review of this examination. In particular, this paper will review
multiple studies that investigate the monoamine (MAO) hypothesis of depression
and metabolic syndrome (MetS) as a risk factor for neurological disorders.While studies that
evaluate additional risk factors for neurological disorders, such as autoimmunity and
rheumatic diseases, oxytocin receptor (OXTR) DNA methylation in postpartum
depression, dietary health in children and their psychological health, and
dietary magnesium and cardiovascular disease, will be reviewed as well.
References
[1]
Hinz, M., Stein, A. and Uncini, T. (2012) The Discrediting of the Monoamine Hypothesis. International Journal of General Medicine, 5, 135-142. https://doi.org/10.2147/IJGM.S27824
[2]
Massart, R., Mongeau, R. and Lanfumey, L. (2012) Beyond the Monoaminergic Hypothesis: Neuroplasticity and Epigenetic Changes in a Transgenic Mouse Model of Depression. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 367, 2485-2494. https://doi.org/10.1098/rstb.2012.0212
[3]
Goldberg, J.S., Bell, C.E. and Pollard, D.A. (2014) Revisiting the Monoamine Hypothesis of Depression: A New Perspective. Perspectives in Medicinal Chemistry, 6, 1-8. https://doi.org/10.4137/PMC.S11375
[4]
Farooqui, A.A., Farooqui, T., Panza, F. and Frisardi, V. (2012) Metabolic Syndrome as a Risk Factor for Neurological Disorders. Cellular and Molecular Life Sciences, 69, 741-762. https://doi.org/10.1007/s00018-011-0840-1
[5]
Kimmel, M., Clive, M., Gispen, F., Guintivano, J., Brown, T., Cox, O., Beckmann, M.W., Kornhuber, J., Fasching, P.A., Osborne, L.M., Binder, E., Payne, J.L. and Kaminsky, Z. (2016) Oxytocin Receptor DNA Methylation in Postpartum Depression. Psychoneuroendocrinology, 69, 150-160. https://doi.org/10.1016/j.psyneuen.2016.04.008
[6]
O’Neil, A., Quirk, S.E., Housden, S., Brennan, S.L., Williams, L.J., Pasco, J.A. and Jack, F.N. (2014) Relationship between Diet and Mental Health in Children and Adolescents: A Systematic Review. American Journal of Public Health, 104, e31-e42. https://doi.org/10.2105/AJPH.2014.302110
[7]
Rosique-Esteban, N., Guasch-Ferré, M., Hernández-Alonso, P. and Salas-Salvadó, J. (2018) Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies. Nutrients, 10, 168. https://doi.org/10.3390/nu10020168
[8]
Brennen, S.E. and Munn, Z. (2021) PRISMA 2020: A Reporting Guideline for the Next Generation of Scientific Reviews. JBI Evidence Synthesis, 19, 906-908. https://doi.org/10.11124/JBIES-21-00112
[9]
Lepeta, K., Lourenco, M.V., Schweitzer, B.C., Martino Adami, P.V., Banerjee, P., Catuara-Solarz, S., de La Fuente Revenga, M., Guillem, A.M., Haidar, M., Ijomone, O.M., Nadorp, B., Qi, L., Perera, N.D., Refsgaard, L.K., Reid, K.M., Sabbar, M., Sahoo, A., Schaefer, N., Sheean, R.K., Suska, A., Seidenbecher, C., et al. (2016) Synaptopathies: Synaptic Dysfunction in Neurological Disorders—A Review from Students to Students. Journal of Neurochemistry, 138, 785-805. https://doi.org/10.1111/jnc.13713
[10]
Shi, J., Fan, J., Su, Q. and Yang, Z. (2019) Cytokines and Abnormal Glucose and Lipid Metabolism. Frontiers in Endocrinology, 10, Article No. 703. https://doi.org/10.3389/fendo.2019.00703
[11]
Cornier, M.A., Dabelea, D., Hernandez, T.L., Lindstrom, R.C., Steig, A.J., Stob, N.R., Van Pelt, R.E., Wang, H. and Eckel, R.H. (2008) The Metabolic Syndrome. Endocrine Reviews, 29, 777-822. https://doi.org/10.1210/er.2008-0024
Stuebe, A.M., Grewen, K., Pedersen, C.A., Propper, C. and Meltzer-Brody, S. (2012) Failed Lactation and Perinatal Depression: Common Problems with Shared Neuroendocrine Mechanisms? Journal of Women’s Health, 21, 264-272. https://doi.org/10.1089/jwh.2011.3083
[14]
Skrundz, M., Bolten, M., Nast, I., Hellhammer, D.H. and Meinlschmidt, G. (2011) Plasma Oxytocin Concentration during Pregnancy Is Associated with Development of Postpartum Depression. Neuropsychopharmacology, 36, 1886-1893. https://doi.org/10.1038/npp.2011.74
[15]
Mamrut, S., Harony, H., Sood, R., Shahar-Gold, H., Gainer, H., Shi, Y.-J., Barki-Harrington, L. and Wagner, S. (2013) DNA Methylation of Specific CPG Sites in the Promoter Region Regulates the Transcription of the Mouse Oxytocin Receptor. PLoS ONE, 8, e56869. https://doi.org/10.1371/journal.pone.0056869
[16]
Franczak, A., Staszkiewicz, J., Koziorowski, M. and Kotwica, G. (2002) The Influence of Estradiol and Progesterone on the Concentrations of Uterine Oxytocin Receptors and Plasma PGFM in Response to Oxytocin in Ovariectomized Gilts. Reproduction Nutrition Development, 42, 327-338. https://doi.org/10.1051/rnd:2002029
[17]
Quiñones-Jenab, V., Jenab, S., Ogawa, S., Adan, R.A.M., Burbach, P.H. and Pfaff, D.W. (1997) Effects of Estrogen on Oxytocin Receptor Messenger Ribonucleic Acid Expression in the Uterus, Pituitary, and Forebrain of the Female Rat. Neuroendocrinology, 65, 9-17. https://doi.org/10.1159/000127160
[18]
Bell, A.F., Carter, C.S., Steer, C.D., Golding, J., Davis, J.M., Steffen, A.D., Rubin, L.H., Lillard, T.S., Gregory, S.P., Harris, J.C. and Connelly, J.J. (2015) Interaction between Oxytocin Receptor DNA Methylation and Genotype Is Associated with Risk of Postpartum Depression in Women without Depression in Pregnancy. Frontiers in Genetics, 6, Article No. 243. https://doi.org/10.3389/fgene.2015.00243
[19]
Jeong, H.-G., Lim, J.-S., Lee, M.-S., Kim, S.-H., Jung, I.-K. and Joe, S.-H. (2013) The Association of Psychosocial Factors and Obstetric History with Depression in Pregnant Women: Focus on the Role of Emotional Support. General Hospital Psychiatry, 35, 354-358. https://doi.org/10.1016/j.genhosppsych.2013.02.009
[20]
Meltzer-Brody, S., Bledsoe-Mansori, S.E., Johnson, N., Killian, C., Hamer, R.M., Jackson, C., Wessel, J. and Thorp, J. (2013) A Prospective Study of Perinatal Depression and Trauma History in Pregnant Minority Adolescents. American Journal of Obstetrics and Gynecology, 208, 211.e1-7. https://doi.org/10.1016/j.ajog.2012.12.020
[21]
Yim, I.S., Tanner Stapleton, L.R., Guardino, C.M., Hahn-Holbrook, J. and Dunkel Schetter, C. (2015) Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration. Annual Review of Clinical Psychology, 11, 99-137. https://doi.org/10.1146/annurev-clinpsy-101414-020426
[22]
Windle, R.J., Gamble, L.E., Kershaw, Y.M., Wood, S.A., Lightman, S.L. and Ingram, C.D. (2006) Gonadal Steroid Modulation of Stress-Induced Hypothalamo-Pituitary-Adrenal Activity and Anxiety Behavior: Role of Central Oxytocin. Endocrinology, 147, 2423-2431. https://doi.org/10.1210/en.2005-1079
[23]
Smith, A.S., Tabbaa, M., Lei, K., Eastham, P., Butler, M.J., Linton, L., Altshuler, R., Liu, Y. and Wang, Z. (2016) Local Oxytocin Tempers Anxiety by Activating GABAA Receptors in the Hypothalamic Paraventricular Nucleus. Psychoneuroendocrinology, 63, 50-58. https://doi.org/10.1016/j.psyneuen.2015.09.017
[24]
Myers, A.J., Williams, L., Gatt, J.M., McAuley-Clark, E.Z., Dobson-Stone, C., Schofield, P.R. and Nemeroff, C.B. (2014) Variation in the Oxytocin Receptor Gene Is Associated with Increased Risk for Anxiety, Stress and Depression in Individuals with a History of Exposure to Early Life Stress. Journal of Psychiatric Research, 59, 93-100. https://doi.org/10.1016/j.jpsychires.2014.08.021
[25]
Farooqui, A.A. (2013) Lifestyle as a Risk Factor for Metabolic Syndrome and Neurological Disorders. In: Farooqui, A.A., Ed., Metabolic Syndrome: An Important Risk Factor for Stroke, Alzheimer Disease, and Depression, Springer, Berlin, 1-34. https://doi.org/10.1007/978-1-4614-7318-3_1
[26]
Pope, C.J. and Mazmanian, D. (2016) Breastfeeding and Postpartum Depression: An Overview and Methodological Recommendations for Future Research. Depression Research and Treatment, 2016, Article ID: 4765310. https://doi.org/10.1155/2016/4765310