Renal biopsy is an invasive procedure used to evaluate the activity and the therapeutic management of kidney disease and kidney transplantation. Objective: The aim of this study was to describe the epidemiological, clinical, and pathological features of kidney disease diagnosed by biopsy in the Ivory Coast. Materials and Methods: This was a descriptive and prospective study conducted between January 2015 and December 2018 in the Department of Anatomy and Cytology of the Pathology of Cocody (Abidjan) and Bouake. Specimens were obtained from the nephrology department of Ivory Coast and from teaching hospitals in Togo, Guinea, Burkina Faso, and Mali. Samples were analyzed according to standard renal biopsy procedures. One kidney fragment was fixed in acetic acid formalin (AAF) for optical microscopy examination. The other fragment, soaked in physiological water, was immediately sent for immunofluorescence examination. All renal pathologies were included in this study. The study parameters were frequency, age, sex, origin, occupation, clinical and biological signs, and pathological aspects with optical microscopy, and immunofluorescence. Results: 153 cases (2.23%) of kidney biopsies were examined on a total of 10,573 specimens. Ivory Coast specimens accounted for 91.5% of cases (n = 140). Nephrotic syndrome (49%) was the most common clinical sign and indication for renal biopsy, followed by acute renal failure (16.3%), chronic renal failure (19.6%), and a combination of chronic renal failure with hypertension (11.18%) and glomerulonephritis (4%). Mean proteinuria was 3.03 g/24h (range, 0.14 to 11.5 g/24h). Histologically, 90.8% (n = 139) were glomerular nephropathies, including 26.6% HIV-associated nephropathy, 17.3% focal segmental glomerulosclerosis, 13.6% nephroangiosclerosis, 11.5% post-infectious glomerulonephritis, 9.3% membranous glomerulonephritis, and 21.6% miscellaneous glomerular nephropathies (n = 30). The incidence of various tubulo-interstitial lesions was 9.2% (n = 14). Conclusion: Glomerular nephropathies represent the most important renal diseases. Young people are most commonly affected with a high prevalence of focal segmental glomerulosclerosis and HIV-associated nephropathy.
References
[1]
Venuthurupalli, S.K., Healu, H.G., Cameron, A. and Fassett, R.G. (2017) CKD.QLD: Establishment of a Chronic Kidney Disease [CKD] Registry. Registry in Queensland Australia. BMC Nephrology, 18, Article No. 189. https://doi.org/10.1186/s12882-017-0607-5
[2]
Abdou, N., Boucar, D., El Hadj Fary, K.A., Mouhamadou, M., Abdoulaye, L., Mamadou Mourtala, K.A., et al. (2003) Histopathological Profiles of Nephropathies in Senegal. Saudi Journal of Kidney Diseases and Transplantation, 14, 212-214.
[3]
Mbarki, H., Belghiti, K.A., Harmouch, T., Najdia, A., Arrayhari, M. and Sqalli, T. (2016) Ponctions biopsies rénales dans le service de Néphrologie de Fès (Maroc). Indications et résultats. A propos de 552 cas. The Pan African Medical Journal, 24, Article No. 21. https://doi.org/10.11604/pamj.2016.24.21.3982
[4]
Fuiano, G., Mazza, G. and Comi, N. (2000) Current Indication for Renal Biopsy: A Questionnaire Based Survey. American Journal of Kidney Diseases, 35, 448-457. https://doi.org/10.1016/S0272-6386(00)70197-1
[5]
Topham, P.S. (2007) Renal Biopsy. In: John, F., Jurgen, F. and Johnson Richard, J., Eds., Comprehensive Clinical Nephrology, 3rd Edition, Mosby Elsevier, Philadelphia, 69-75.
[6]
Simon, P., Ramee, M.P., Boulahrouz, R., Stanescu, C., Charasse, C., Ang, K.S., et al. (2004) Epidemiologic Data of Primary Glomerular Diseases in Western France. Kidney International, 66, 905-908. https://doi.org/10.1111/j.1523-1755.2004.00834.x
[7]
Maixnerova, D., Jancova, E., Skibova, J., Rysava, R., Rychlik, I., Viklicky, O., et al. (2015) Nationwide Biopsy Survey of renal Diseases in the Czech Republic during the Years 1994-2011. Journal of Nephrology, 28, 39-49. https://doi.org/10.1007/s40620-014-0090-z
[8]
Jegatheesan, D., Nath, K., Reyaldeen, R., Sivasuthan, G., John, G.T., Francis, L., et al. (2016) Epidemiology of Biopsyproven Glomerulonephritis in Queensland Adults. Nephrology, 21, 28-34. https://doi.org/10.1111/nep.12559
[9]
Sugiyama, H., Yokoyama, H., Sato, H., Saito, T., Kohda, Y., Nishi, S., et al. (2013) Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010. Clinical and Experimental Nephrology, 17, 155-173. https://doi.org/10.1007/s10157-012-0746-8
[10]
Chang, J.H., Kim, D.K., Kim, H.W., Park, S.Y., Yoo, T.H., Kim, B.S., et al. (2009) Changing Prevalence of Glomerular Diseases in Korean Adults: A Review of 20 Years of Experience. Nephrology Dialysis Transplantation, 24, 2406-2410. https://doi.org/10.1093/ndt/gfp091
[11]
Xu, X., Wang, G., Chen, N., Lu, T., Nie, S., Xu, G., et al. (2016) Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China. Journal of the American Society of Nephrology, 27, 3739-3746. https://doi.org/10.1681/ASN.2016010093
[12]
Haas, M., Spargo, B.H. and Coventry, S. (1995) Increasing Incidence of Focal-Segmental Glomerulosclerosis among Adult Nephropathies: A 20-Year Renal Biopsy Study. American Journal of Kidney Diseases, 26, 740-750. https://doi.org/10.1016/0272-6386(95)90437-9
[13]
Korbet, S.M., Genchi, R.M., Borok, R.Z. and Schwartz, M.M. (1996) The Racial Prevalence of Glomerular Lesions in Nephrotic Adults. American Journal of Kidney Diseases, 27, 647-651. https://doi.org/10.1016/S0272-6386(96)90098-0
[14]
Polito, M.G., de Moura, L.A. and Kirsztajn, G.M. (2010) An Overview on Frequency of Renal Biopsy Diagnosis in Brazil: Clinical and Pathological Patterns Based on 9,617 Native Kidney Biopsies. Nephrology Dialysis Transplantation, 25, 490-496. https://doi.org/10.1093/ndt/gfp355
[15]
Okpechi, I., Swanepoel, C., Duffield, M., Mahala, B., Wearne, N., Alagbe, S., et al. (2011) Patterns of Renal Disease in Cape Town South Africa: A 10-Year Review of a Single-Centre Renal Biopsy Database. Nephrology Dialysis Transplantation, 26, 1853-1861. https://doi.org/10.1093/ndt/gfq655
[16]
Rivera, F., Lopez-Gomez, J.M. and Perez-Garcia, R. (2004) Clinicopathologic Correlations of Renal Pathology in Spain. Kidney International, 66, 898-904. https://doi.org/10.1111/j.1523-1755.2004.00833.x
[17]
National Institution of Statistics of Côte d’Ivoire (2015) Census of the General Population of Côte d’Ivoire in 2015. http://www.ins.ci/n
[18]
Summary of accelerated actions—Côte d'Ivoire—Portail in Côte d'Ivoire (2019-2020). https://psgouv.ci/welcome/details_sous_menu_gr3/point-synthetique-des-acti%20ons-menees884
[19]
Das, U., Dakshinamurty, K.V. and Prayaga, A. (2011) Pattern of Biopsy-Proven Renal Disease in a Single Center of South India. Indian Journal of Nephrology, 21, 250-257. https://doi.org/10.4103/0971-4065.85482
[20]
Agarwal, S.K. and Dash, S.C. (2000) Spectrum of Renal Diseases in Indian Adults. Journal of the Association of Physicians of India, 48, 594-600.
[21]
Research Group on Progressive Chronic Renal disease (1999) Nationwide and Long-Term Survey of Primary Glomerulonephritis in Japan as Observed in 1,850 Biopsied Cases. Nephron, 82, 205-213. https://doi.org/10.1159/000045404
[22]
Gesualdo, L., Di Palma, A.M., Morrone, L.F., Strippoli, G.F. and Schena, F.P. (2004) The Italian Regimen of Renal Biopsies. Kidney International, 66, 890-894. https://doi.org/10.1111/j.1523-1755.2004.00831.x
[23]
Fabian, J. and Naicker, S. (2009) HIV and Kidney Disease in Sub-Saharan Africa. Nature Reviews Nephrology, 5, 591-598. https://doi.org/10.1038/nrneph.2009.141
[24]
Rao, T.K. (2001) Human Immunodeficiency Virus Infection and Renal Failure. Infectious Disease Clinics of North America, 15, 833-850. https://doi.org/10.1016/S0891-5520(05)70175-6
[25]
Cisse, M., Fall, K., Ka, E.H.F., Lemrabott, A.T., Faye, M., Abdoul Karim, D., Niang, A. and Diouf, B. (2015) Renal Impairment during HIV Infection in Dakar: About 32 Cases. Nephrology Therapy, 11, 371. https://doi.org/10.1016/j.nephro.2015.07.333
[26]
Levin, M.L., Palella, F., Shah, S., Lerma, E., Butter, J. and Kanwar, Y.S. (2001). HIV-Associated Nephropathy Occurring before HIV Antibody Seroconversion. American Journal of Kidney Diseases, 37, E39.1-E39.5. https://doi.org/10.1016/S0272-6386(05)90003-6
[27]
Gerntholtz, T.E., Goetsch, S.J. and Katz I (2006). HIV-Related Nephropathy: A South African Perspective. Kidney International, 69, 1885-1891. https://doi.org/10.1038/sj.ki.5000351
[28]
Wearne, N., Swanepoel, C.R., Boulle, A., Duffield, M.S. and Rayner, B.L (2012). The Spectrum of Renal Histology Seen in HIV with Outcomes, Prognostic Indicators and Clinical Correlations. Nephrology Dialysis Transplantation, 27, 4109-1418. https://doi.org/10.1093/ndt/gfr702
[29]
Barisoni, L., Schnaper, H.W. and Kopp, J.B. (2007) Proposed Taxonomy for the Podocytopathies: A Reassessment of the Primary Nephrotic Diseases. Clinical Journal of the American Society of Nephrology, 2, 529-542. https://doi.org/10.2215/CJN.04121206
