Alkaptonuria is a rare inherited tyrosine metabolism
disorder, resulting in homogentisic acid deposition in the connective tissues.
The condition is commonly referred to as ochronosis and manifests as skin
pigmentation, degenerative arthropathy, and black urine. Among the rare
complications of this disease is the involvement of the cardiovascular system.
We report a case of a 63-year-old woman with alkaptonuric ochronosis who had
already undergone three joint replacements. She was referred to our center for
aortic valve replacement after accidentally discovering severe aortic valve
stenosis in the preoperative assessment prior to her fourth joint replacement.
Intraoperative findings included ochronosis of a severely calcified
black-pigmented aortic valve and black pigmentation of the aortic intima.
Histopathological analysis and elevated homogentisic acid levels in the patient’s urine confirmed the
diagnosis of alkaptonuria. However, alkaptonuria was not diagnosed until aortic
valve replacement despite the previous symptoms and signs. This report aims to
outline the history, etiology, pathogenesis, clinical presentation, and
treatment of aortic valve ochronosis in addition to presenting the case.
References
[1]
Ranganath, L.R., Jarvis, J.C. and Gallagher, J.A. (2013) Recent Advances in Management of Alkaptonuria (Invited Review; Best Practice Article). Journal of Clinical Pathology, 66, 367-373. https://doi.org/10.1136/jclinpath-2012-200877
[2]
Janocha, S., Wolz, W., Srsen, S., Srsnova, K., Montagutelli, X., Guénet, J.L., Grimm, T., Kress, W. and Müller, C.R. (1994) The Human Gene for Alkaptonuria (AKU) Maps to Chromosome 3q. Genomics, 19, 5-8. https://doi.org/10.1006/geno.1994.1003
[3]
Groseanu, L., Marinescu, R., Laptoiun, D., Botezatu, I., Staniceanu, F., Zurac, S., et al. (2010) A Late and Difficult Diagnosis of Ochronosis. Journal of Medicine and Life, 3, 437-443.
[4]
Kottinen, Y.T., Hoikka, V., Landtman, M., Saari, H., Santavirta, S., Metsarinne, K. and Seegmiller, J.E. (1989) Ochronosis: A Report of a Case and a Review of Literature. Clinical and Experimental Rheumatology, 7, 435-444.
[5]
Stenn, F.F., Milgram, J.W., Lee, S.L., Weigand, R.J. and Veis, A. (1977) Biochemical Identification of Homogentisic Acid Pigment in an Ochronotic Egyptian Mummy. Science, 197, 566-568. https://doi.org/10.1126/science.327549
[6]
Fernández-Cañón, J.M., Granadino, B., Beltrán-Valero de Bernabé, D., Renedo, M., Fernández-Ruiz, E. and Peñalva, M.A. and Rodríguez de Córdoba, S. (1996) The Molecular Basis of Alkaptonuria. Nature Genetic, 14, 19-24. https://doi.org/10.1038/ng0996-19
[7]
Peker, E., Yonden, Z. and Sogut, S. (2008) From Darkening Urine to Early Diagnosis of Alkaptonuria. Indian Journal of Dermatology, Venereology and Leprology, 74, Article No. 700. https://doi.org/10.4103/0378-6323.45142
[8]
Keller, J.M., Macaulay, W., Nercessian, O.A. and Jaffe, I.A. (2005) New Developments in Ochronosis: Review of the Literature. Rheumatology International, 25, 81-85. https://doi.org/10.1007/s00296-004-0498-1
[9]
Gaines Jr, J.J. and Pai, G.M. (1987) Cardiovascular Ochronosis. Archives of Pathology & Laboratory Medicine, 111, 991-994.
[10]
Cercek, M., Prokselj, K. and Kozelj, M. (2002) Aortic Valve Stenosis in Alkaptonuric Ochronosis. The Journal of Heart Valve Disease, 11, 386-388.
[11]
Pettit, S.J., Fisher, M., Gallagher, J.A. and Ranganath, L.R. (2011) Cardiovascular Manifestations of Alkaptonuria. Journal of Inherited Metabolic Disease, 34, 1177-1181. https://doi.org/10.1007/s10545-011-9339-z
[12]
Mori, S., Kawaguchi, T., Kakinuma, H., et al. (1994) Alcaptonuria: A Case Complicated with Valvular Heart Disease and Immunodeficiency. Internal Medicine, 33, 512-516. https://doi.org/10.2169/internalmedicine.33.512
[13]
Mayatepek, E., Kallas, K., Anninos, A., et al. (1998) Effects of Ascorbic Acid and Lowprotein Diet in Alkaptonuria. European Journal of Pediatrics, 157, 867-868. https://doi.org/10.1007/s004310050956
[14]
Ranganath, L.R., Khedr, M. and Milan, A.M. (2018) Nitisinone Arrests Ochronosis and Decreases Rate of Progression of Alkaptonuria: Evaluation of the Effect of nItisinone in the United Kingdom National Alkaptonuria Centre. Molecular Genetics and Metabolism, 125, 127-134. https://doi.org/10.1016/j.ymgme.2018.07.011