At present, there are some concerns and problems to
treat neurointensive care patients by using analgesics and sedatives.
Conditions of neurointensive care patients change quickly. For neurointensive
care patients who cannot have auxiliary examination timely, clinicians judge
intracranial conditions mainly through relevant monitoring devices and
consciousness and pupil changes of patients.
The use of analgesics and sedatives is limited due to worry about influences on consciousness evaluation and
judgment and different degrees of inhibition on cardiovascular system and
respiratory system. Common sedatives (e.g.
benzodiazepines) and common analgesics (e.g. morphine, fentanyl and
sufentanil) both may inhibit respiration. The specification often provides
taboos for the use of drugs by patients with increase intracranial pressure
(ICP) and craniocerebral injuries. Through literature review, the author
analyzed influences of analgesics and sedatives on ICP of neurointensive care
patients comprehensively.
References
[1]
Wan, J., Fan, Q., Fan, C.H., et al. (2020) Effects of Combined Administration of Dexmedetomidine Hydrochloride and Butorphanol Tartrate on Stress State, NPAS4 and NSE of Old Patients with Craniocerebral Trauma. Journal of Clinical and Experimental Medicine, 19, 2037-2041.
[2]
Wang, B.L., Wang, H.X., Zhou, H.X., et al. (2018) Analgesia and Sedation Effect Observation of Dexmedetomidine-Butorphanol Combination in Patients with Hypertensive Intracerebral Hemorrhage. Chinese Journal of Clinical Neurosurgery, 23, 792-794.
[3]
Zhang, X.F., Yin, Z.W., Wu, W., et al. (2021) Effect Evaluation of Butorphanol-Dexmedetomidine Combination in Patients with Craniocerebral Trauma in ICU. Chinese and Foreign Medical Research, 19, 47-50.
https://doi.org/10.4236/cm.2021.123006
[4]
Zhou, Q.Y., Liu, Y., Gao, L., et al. (2021) Application Effects of Different Doses of Butorphanol Combined with Dexmedetomidine in Patients with Severe Craniocerebral Trauma. Henan Medical Research, 30, 1178-1181.
[5]
Huang, X.L., Kong, B., Fu, Y.Y., et al. (2020) Evaluation of Analgesic Effect of Butorphanol-Dexmedetomidine Combination in Patients with Craniocerebral Trauma. Leading Medicines, 10, 110-111.
[6]
Liu, P.F., Feng, J.F., Wang, W.F., et al. (2020) Effect of Analgesic and Sedative Treatments on Intracranial Pressure in Patients with Severe Traumatic Brain Injury. Chinese Journal of Neurosurgery, 36, 1026-1029.
[7]
Xu, F., Shen, L.J., Zhong, X.M., et al. (2018) Effects of Sedation and Analgesia on Postoperative Intracranial Pressure in Patients with Severe Traumatic Brain Injury. Chinese Journal of Neurotraumatic Surgery (Electronic Edition), 4, 276-278.
[8]
Zhang, M., Hu, Y.L., Zhen, H., et al. (2019) Effects of Analgesics and Sedatives on ICP of Patients with Severe Craniocerebral Injury. Clinical Research, 27, 110-112.
[9]
Lu, Z.Q. (2016) Effects of Analgesics and Sedatives on ICP and Curative Effects in Patients with Traumatic Intracranial Hypertension in ICU. Medical Theory and Practice, 29, 3039-3040.
[10]
Zhen, X.Y. (2016) Effects of Analgesics and Sedatives on Curative Effects and ICP in Patients with Traumatic Intracranial Hypertension in ICU. Electronic Journal of Clinical Medicine Literature, 3, 7961.
[11]
Zhuang, M.Z. (2014) Effects of Analgesics and Sedatives on ICP and Curative Effects in Patients with Traumatic Intracranial Hypertension in ICU. China Practical Medical, No. 34, 146-147.
[12]
Wu, Y.F. (2015) Effects of Analgesics and Sedatives on ICP and Curative Effects in Patients with Traumatic Intracranial Hypertension in ICU. Contemporary Medicine, No. 30, 60-61.
[13]
Wu, Z.H. and Song, Q. (2014) Effects of Analgesics and Sedatives on ICP and Curative Effects in Patients with Traumatic Intracranial Hypertension in ICU. Journal of Modern Integrated Chinese and Western Medicine, 23, 732-733.
[14]
Chen, X.G., Li, W.L., Wang, K.P., et al. (2017) Clinical Effect of Sedation Analgesia Treatment in Patients with Hypertensive Intracerebral Hemorrhage after Operation. Medicine and Philosophy, 38, 44-47.
[15]
Li, J. (2019) Clinical Effect of Post-Operative Analgesics and Sedatives in Patients with Hypertensive Cerebral Hemorrhage. Journal of General Stomatology (E-Version), 6, 170-171.
[16]
Yang, M.X., Lu, W.T., Lai, J.L., et al. (2019) Observation on Curative Effect of ICU Continuous Deep Sedation Analgesia on Reducing the Postoperative Intracranial Pressure of Patients with Spontaneous Intracerebral Hemorrhage. Clinical Medical & Engineering, 26, 607-608.
[17]
Liu, J.S., Zhang, Y.J., Song, D.G., et al. (2019) Analysis on Curative Effect of Post-Operative Analgesics and Sedatives in Hypertensive Cerebral Hemorrhage. Zhejiang Trauma Surgery Department, 24, 1042-1043.
[18]
Girard, F., Moumdjian, R., Boudreault, D., et al. (2004) The Effect of Propofol Sedation on the Intracranial Pressure of Patients with an Intracranial Space-Occupying Lesion. Anesthesia & Analgesia, 99, 573-577.
https://doi.org/10.1213/01.ANE.0000133138.86133.38
