In this work, we show the synthesis of ten (10) new derivatives of
3-imidazo[1,2-a]pyridinyl-1-arylpropenone (10a - d). These new compounds were
obtained by condensation of Claisen-Schmidt between derivatives of 2-substi- tuted-1H-imidazo[1,2-a]pyridine-3-carbaldehyde
(3a - b and 7) and acetophenone derivatives (9a - e) in the presence of
a base. The synthesized compounds were characterized by spectroscopic analyses 1H
and 13C NMR. The antifungal activity of the ten (10) derivatives was
determined on a resistant strain of Candidaalbicans by the microdilution method. The results showed
that four (4) of them (10a, 10b, 10c and 10i) were active with minimum
inhibitory concentrations (MICs) below 300 μmol/L. Of these four compounds, 10i
was more potent than the others with a MIC of 41.98 μmol/L.
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