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Warfarin Compliance after Mechanical AVR in the Pediatric Population: Case Series from a Developing Country

DOI: 10.4236/wjcs.2022.128014, PP. 184-190

Keywords: Mechanical AVR, Warfarin, INR monitoring, Anticoagulant, Thromboembolic

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Abstract:

Background and Aim: Mechanical prosthetic heart valves exert a lifelong thromboembolic complication requiring continuous antithrombotic therapy. Vitamin K antagonist is the recommended therapy of choice along with meticulous INR monitoring to achieve and maintain an INR of 2.0 - 3.0. The study aimed to assess the compliance of anticoagulant therapy in pediatric patients after AVR and to highlight the challenges faced during follow-ups. Methods: A retrospective study was conducted at NICVD Hospital in Karachi, Pakistan for a time frame of 2 years from 2020-2021 where 7 patients were selected. Data were collected using hospital medical records and then validated through a phone call mediated structured questionnaire-based interview. Results: 2 out of 7 patients in the case

References

[1]  Watkins, D.A., Johnson, C.O., Colquhoun, S.M., et al. (2017) Global, Regional, and National Burden of Rheumatic Heart Disease, 1990-2015. The New England Journal of Medicine, 377, 713-722.
https://doi.org/10.1056/NEJMoa1603693
[2]  Whitlock, R.P., Sun, J.C., Fremes, S.E., Rubens, F.D. and Teoh, K.H. (2012) Antithrombotic and Thrombolytic Therapy for Valvular Disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th Ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 141, E576S-E600S.
https://doi.org/10.1378/chest.11-2305
[3]  Little, S.H. and Massel, D.R. (2003) Antiplatelet and Anticoagulant for Patient with Prosthetic heart Valves. Cochrane Database of Systematic Reviews, No. 4, Article No. CD003464.
https://doi.org/10.1002/14651858.CD003464
[4]  Myers, P.O., Mokashi, S.A., Horgan, E., Borisuk, M., Mayer Jr., J.E., Del Nido, P.J, and Baird, C.W. (2019) Outcomes after Mechanical Aortic Valve Replacement in Children and Young Adults with Congenital Heart Disease. The Journal of Thoracic and Cardiovascular Surgery, 157, 329-340.
https://doi.org/10.1016/j.jtcvs.2018.08.077
[5]  Riaz, H., Alansari, S.A., Khan, M.S., et al. (2016) Safety and Use of Anticoagulation after Aortic Valve Replacement with Bioprostheses: A Meta-Analysis. Circulation: Cardiovascular Quality and Outcomes, 9, 294-302.
https://doi.org/10.1161/CIRCOUTCOMES.115.002696
[6]  Lakshmi, R., Anitha, S., Anila, K.N. and Roshni, P.R. (2012) Warfarin Resistance Mechanisms and Management. International Journal of Pharma Sciences and Research, 3, 353-357.
[7]  Monagle, P. and Newall, F. (2018) Management of Thrombosis in Children and Neonates: Practical Use of Anticoagulants in Children. Hematology, ASH Education Program, 2018, 399-404.
https://doi.org/10.1182/asheducation-2018.1.399
[8]  Puskas, J.D., Gerdisch, M., Nichols, D., et al. (2018) Anti-Coagulation and Antiplatelet Strategies after On-X Mechanical Aortic Valve Replacement. Journal of the American College of Cardiology, 71, 2717-2726.
https://doi.org/10.1016/j.jacc.2018.03.535
[9]  Jawitz, O.K., Wang, T.Y., Lopes, R.D., Chavez, A., et al. (2020) Rationale and Design of PROACT Xa: A Randomized, Multicentre, Open-Label, Clinical Trial to Evaluate the Efficacy and Safety of Apixaban versus Warfarin in Patients with a Mechanical On-X Aortic Heart Valve. American Heart Journal, 227, 91-99.
https://doi.org/10.1016/j.ahj.2020.06.014
[10]  Lopes, R.D., Alexander, J.H., Al-Khatib, S.M., et al. (2010) Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial: Design and Rationale. American Heart Journal, 159, 331-339.
https://doi.org/10.1016/j.ahj.2009.07.035
[11]  Touma, L., Filion, K.B., Atallah, R., et al. (2015) A Meta-Analysis of Randomized Controlled Trials of the Risk of Bleeding with Apixaban versus Vitamin K Antagonists. The American Journal of Cardiology, 115, 533-541.
https://doi.org/10.1016/j.amjcard.2014.11.039
[12]  van Zyl, M., Wysokinski, W.E., Jaeger, T.M., Casanegra, A.I., Gersh, B.J. and McBane, R.D. (2020) In-Home Compared with In-Clinic Warfarin Therapy Monitoring in Mechanical Heart Valves: A Population-Based Study. Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 4, 511-520.
https://doi.org/10.1016/j.mayocpiqo.2020.05.003

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