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雌马酚抗菌作用的研究现状及前景展望
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Abstract:
雌马酚是由大豆异黄酮在肠道微生物菌群作用下合成的一类雌激素类似物。其对雌激素受体的亲和力高，且具有比大豆异黄酮更高的生物学活性，是目前研究较为广泛的小分子物质之一。雌马酚具有激素样作用、抗氧化、免疫调节等多种生物学作用。本文主要对雌马酚的生物学活性及抗菌作用研究方面进行综述，旨在为雌马酚在抗菌治疗方面提供新的思路。
Equol, is a kind of phytoestrogenic compound, which synthesized by soybean isoflavones by intestinal microbiota. It has high affinity for estrogen receptor and higher biological activity than soybean isoflavones, so it is one of the widely studied small molecule substances. Equol has many biological effects, such as hormone like effect, antioxidation, immune regulation, etc. In this paper, the biological activity and antibacterial effect of equol were reviewed, in order to provide new ideas for the antibacterial treatment of equol.
| [1] | Shor, D., Sathyapalan, T., Atkin, S.L. and Thatcher, N.J. (2012) Does Equol Production Determine Soy Endocrine Effects? European Journal of Nutrition, 51, 389-398. https://doi.org/10.1007/s00394-012-0331-7 |
| [2] | Marrian, G.F. and Haslewood, G.A. (1932) Equol, a New Inactive Phenol Isolated from the Ketohydroxyoestrin Fraction of Mares’ Urine. Biochemical Journal, 26, 1227-1232. https://doi.org/10.1042/bj0261227 |
| [3] | Sathyamoorthy, N. and Wang, T.T. (1997) Differential Effects of Dietary Phyto-Oestrogens Daidzein and Equol on Human Breast Cancer MCF-7 Cells. European Journal of Cancer, 33, 2384-2389.
https://doi.org/10.1016/S0959-8049(97)00303-1 |
| [4] | 李燕, 蒋守群, 陈伟. 雌马酚的产生、生物学功能及潜在应用[J]. 动物营养学报, 2014, 26(11): 3236-3244. |
| [5] | Fatima, A., Khan, M.S. and Ahmad, M.W. (2020) Therapeutic Potential of Equol: A Comprehensive Review. Current Pharmaceutical Design, 26, 5837-5843. https://doi.org/10.2174/1381612826999201117122915 |
| [6] | Gopaul, R., Knaggs, H.E. and Lephart, E.D. (2012) Biochemical Investigation and Gene Analysis of Equol: A Plant and Soy-Derived Isoflavonoid with Antiaging and Antioxidant Properties with Potential Human Skin Applications. Biofactors, 38, 44-52. https://doi.org/10.1002/biof.191 |
| [7] | Hirvonen, J., Rajalin, A.M., Wohlfahrt, G., Adlercreutz, H., W？h？l？, K. and Aarnisalo, P. (2011) Transcriptional Activity of Estrogen-Related Receptor γ (ERRγ) Is Stimulated by the Phytoestrogen Equol. The Journal of Steroid Biochemistry and Molecular Biology, 123, 46-57. https://doi.org/10.1016/j.jsbmb.2010.11.001 |
| [8] | Sekikawa, A., Ihara, M., Lopez, O., et al. (2019) Effect of S-Equol and Soy Isoflavones on Heart and Brain. Current Cardiology Reviews, 15, 114-135. https://doi.org/10.2174/1573403X15666181205104717 |
| [9] | Alfa, H.H. and Arroo, R.R.J. (2019) Over 3 Decades of Research on Dietary Flavonoid Antioxidants and Cancer Prevention: What Have We Achieved? Phytochemistry Reviews, 18, 989-1004.
https://doi.org/10.1007/s11101-019-09632-0 |
| [10] | Fang, K., Dong, H., Wang, D., Gong, J., Huang, W. and Lu, F. (2016) Soy Isoflavones and Glucose Metabolism Inmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Molecular Nutrition & Food Research, 60, 1602-1614. https://doi.org/10.1002/mnfr.201501024 |
| [11] | Arora, A., Nair, M.G. and Strasburg, G.M. (1998) Antioxidant Activities of Isoflavones and Their Biological Metabolites in a Liposomal System. Archives of Biochemistry and Biophysics, 356, 133-141.
https://doi.org/10.1006/abbi.1998.0783 |
| [12] | Rüfer, C.E. and Kulling, S.E. (2006) Antioxidant Activity of Isoflavones and Their Major Metabolites Using Different in Vitro Assays. Journal of Agricultural and Food Chemistry, 54, 2926-2931. https://doi.org/10.1021/jf053112o |
| [13] | Chung, J.E., Kim, S.Y., Jo, H.H., et al. (2008) Antioxidant Effects of Equol on Bovine Aortic Endothelial Cells. Biochemical and Biophysical Research Communications, 375, 420-424. https://doi.org/10.1016/j.bbrc.2008.08.027 |
| [14] | Cheng, C., Wang, X., Weakley, S.M., et al. (2010) The Soybean Isoflavonoid Equol Blocks Ritonavir-Induced Endothelial Dysfunction in Porcine Pulmonary Arteries and Human Pulmonary Artery Endothelial Cells. The Journal of Nutrition, 140, 12-17. https://doi.org/10.3945/jn.109.110981 |
| [15] | Mayo, B., Vázquez, L. and Flórez, A.B. (2019) Equol: A Bacterial Metabolite from the Daidzein Isoflavone and Its Presumed Beneficial Health Effects. Nutrients, 11, Article No. 2231. https://doi.org/10.3390/nu11092231 |
| [16] | Tanaka, Y., Kimura, S., Ishii, Y. and Tateda, K. (2019) Equol Inhibits Growth and Spore Formation of Clostridioides difficile. Journal of Applied Microbiology, 127, 932-940. https://doi.org/10.1111/jam.14353 |
| [17] | Suay-García, B. and Pérez-Gracia, M.T. (2019) Present and Future of Carbapenem-Resistant Enterobacteriaceae (CRE) Infections. Antibiotics (Basel), 8, Article No. 122. https://doi.org/10.3390/antibiotics8030122 |
| [18] | Sanhueza, L., Melo, R., Montero, R., Maisey, K., Mendoza, L. and Wilkens, M. (2017) Synergistic Interactions between Phenolic Compounds Identified in Grape Pomace Extract with Antibiotics of Different Classes against Staphylococcus aureus and Escherichia coli. PLOS ONE, 12, e0172273. https://doi.org/10.1371/journal.pone.0172273 |
| [19] | Hossain, M.A., Park, H.C., Park, S.W., et al. (2020) Synergism of the Combination of Traditional Antibiotics and Novel Phenolic Compounds against Escherichia coli. Pathogens, 9, Article No. 811.
https://doi.org/10.3390/pathogens9100811 |
| [20] | Kim, H.R. and Eom, Y.B. (2021) Synergistic Activity of Equol and Meropenem against Carbapenem-Resistant Escherichia coli. Antibiotics (Basel), 10, Article No. 161. https://doi.org/10.3390/antibiotics10020161 |
| [21] | Al-Hatmi, A.M.S., Mohsin, J., Al-Huraizi, A. and Khamis, F. (2021) COVID-19 Associated Invasive Candidiasis. Journal of Infection, 82, e45-e46. https://doi.org/10.1016/j.jinf.2020.08.005 |
| [22] | Govender, N.P., Todd, J., Nel, J., et al. (2021) HIV Infection as Risk Factor for Death among Hospitalized Persons with Candidemia, South Africa, 2012-2017. Emerging Infectious Diseases, 27, 1607-1615.
https://doi.org/10.3201/eid2706.210128 |
| [23] | San-Juan, R., Aguado, J.M., Lumbreras, C., et al. (2011) Universal Prophylaxis with Fluconazole for the Prevention of Early Invasive Fungal Infection in Low-Risk Liver Transplant Recipients. Transplantation, 92, 346-350.
https://doi.org/10.1097/TP.0b013e3182247bb4 |
| [24] | Lee, J.A. and Chee, H.Y. (2010) In Vitro Antifungal Activity of Equol against Candida albicans. Mycobiology, 38, 328-330. https://doi.org/10.4489/MYCO.2010.38.4.328 |
