Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare
entities that are similar both in terms of clinical morphological
characteristics and histological characteristics.We report the case of a 49-year-old non-menopausal woman with a history
of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic
consultation was performed. Clinical examination revealed a firm 25 mm mass on
the medial part of the left breast with skin involvement. A biopsy was
performed and analysis result came back in favor of a cellular type
myofibroblastoma showing a fibrous component consisting of spindle cells with a
herringbone arrangement. Anatomopathological results concluded to a
dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor
population strongly positive for CD34 expression. The search for a
rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in
situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of
Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical
treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of
the lesions with margins greater than 2 cm, on which the prognosis mainly
depends. Micrographic surgery and oncoplastic breast surgery are of major
interest in this location.
References
[1]
Darier, J. and Ferrand, M. (1924) Dermatofibromes progressifs et récidivants ou fibrosarcomes de la peau. Ann Dermat Syphil, 5, 545-562.
[2]
Bouhani, M., Fertani, Y., et al. (2019) Dermatofibrosarcoma Protuberans of the Breast in Man: An Extremely Rare Entity with a Review of the Literature. Journal of Investigative Medicine High Impact Case Reports, 7, 1-5.
https://doi.org/10.1177/2324709619875634
[3]
Karam, H., Reda. B. and Abderraouf, S. (2012) Le dermatofibrosarcome protuberans mammaire: Une localisation rare. Imagerie de la Femme, 22, 120-123.
https://doi.org/10.1016/j.femme.2012.04.002
[4]
Bilger, G., Nicolaï, M., Perez, M., et al. (2021) Cas clinique: Reconstruction par abdominoplastie inversée et transposition ombilicale d’un dermatofibrosarcome épigastrique. Annales de Chirurgie Plastique Esthétique, 66, 261-267.
https://doi.org/10.1016/j.anplas.2021.02.001
[5]
Brooke, H., Christopher, D.M., Fletcher, C.D., et al. (2016) Mammary Type Myofibroblastoma Clinicopathologic Characterization in a Series of 143 Cases. The American Journal of Surgical Pathology, 40, 361-367.
https://doi.org/10.1097/PAS.0000000000000540
[6]
Valli, R., Rossi, G., Natalini, G., et al. (2002) Dermatofibrosarcoma protuberans della mammella: Descrizione di un caso. Pathologica, 49, 310-313.
https://doi.org/10.1007/s102420200055
[7]
NCCN Clinical Practice Guidelines in Oncology. Dermatofibrosarcoma Protuberans. Version 1. 2022.
[8]
Labhali, O., Azami, A., Tbouda, M., et al. (2017) Un myofibroblastome de type mammaire pas comme les autres: à propos d’un cas. Pan African Medical Journal, 26, Article No. 69. https://doi.org/10.11604/pamj.2017.26.69.11339
[9]
Wargotz, E.S., Weiss, S.W. and Norris, H.J. (1987) Myofibroblastoma of the Breast Sixteen Cases of a Distinctive Benign Mesenchymal Tumor. The American Journal of Surgical Pathology 11, 493-502.
https://doi.org/10.1097/00000478-198707000-00001
[10]
Magro, G. (2008) Mammary Myofibroblastoma: A Tumor with a Wide Morphologic Spectrum. Archives of Pathology & Laboratory Medicine, 132, 1813-1820.
https://doi.org/10.5858/132.11.1813
[11]
Magro, G., Righi, A., Casorzo, L., et al. (2012) Mammary and Vaginal Myofibroblastoma Are Genetically Related Lesion: FISH Analysis Showing Deletion of 13q14 Regions. Human Pathology, 43, 1887-1893.
https://doi.org/10.1016/j.humpath.2012.01.015
[12]
Castle, K.O., Guadagnolo, B.A., Tsai, C.J., et al. (2013) Dermatofibrosarcoma Protuberans: Long-Term Outcomes of 53 Patients Treated with Conservative Surgery and Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics, 86, 585-590. http://www.ncbi.nlm.nih.gov/pubmed/23628134
https://doi.org/10.1016/j.ijrobp.2013.02.024
[13]
McArthur, G.A. (2007) Molecular Targeting of Dermatofibrosarcoma Protuberans: A New Approach to a Surgical Disease. Journal of the National Comprehensive Cancer Network, 5, 557-562. http://www.ncbi.nlm.nih.gov/pubmed/17509258
https://doi.org/10.6004/jnccn.2007.0049
[14]
Chargui, R., Damak, T., Khomsi, F., et al. (2006) Dermatofibrosarcome de Darier et Ferrand de siège mammaire. Tunisie Medicale, 84, 122-124.