Background: The deep understanding of pathogenesis is a key moment in the formation of the modern strategy of modern medicine. We conducted the thorough analysis of the microscopic processes occurring in the bodies of patients with purulent-septic complications. The modified pathogenetic concept of the diagnostic and treatment model of diseases with septic complications is presented. The obtained information about the mechanisms of origin and development of these diseases is fundamentally important for finding the modern effective methods of treating patients. The aim of the research is to modify treatment tactics for patients with sepsis and burn injuries based on the modified pathogenetic concept using modern diagnostics, i.e. the method of fluorescence spectroscopy (MFS) and biomarkers. Materials and Methods: The proposed modified pathogenetic concept of the diagnostic and treatment model of diseases with purulent-septic complications along with standard methods was used successfully for effective treatment of 15 patients with sepsis and 25 with burn injuries. Results: 3 main scenarios of behaviour of spectral-fluorescence characteristics of patients with sepsis are illustrated. Spectral-fluorescence markers of sepsis were studied, which are informative 24 to 48 hours before the appearance of obvious clinical and laboratory signs of significant changes in the general somatic status of patients. Conclusions: The proposed diagnostic and therapeutic approach is new and fundamentally important for diagnostics and monitoring of the process of treatment of patients with purulent-septic diseases and burn injuries. An in-depth understanding of the dynamics of septic complications and the corresponding changes of the main markers of these diseases during treatment is especially relevant. The use of infusion therapy with solutions of donor albumin as an effective pathogenetic treatment is scientifically justified.
References
[1]
Finnerty, C.C., Herndon, D.N., et al. (2006) Cytokine Expression Profile over Time in Severely Burnes Pediatric Patients. Shock, 26, 13-19. https://doi.org/10.1097/01.shk.0000223120.26394.7d
[2]
Finnerty, C.C., Herndon, D.N., Chinkes, D.L. and Jeschke, M.G. (2007) Serum Cytokine Differences in Severely Burned Children with and without Sepsis. Shock, 27, 4-9. https://doi.org/10.1097/01.shk.0000235138.20775.36
[3]
Faix, J.D. (2013) Biomarkers of Sepsis. Critical Reviews in Clinical Laboratory Sciences, 50, 23-26. https://doi.org/10.3109/10408363.2013.764490
[4]
Lopez, O.N., Cambiaso-Daniel, J., Branski, L.K., et al. (2017) Predicting and Managing Sepsis in Burn Patients: Current Perspectives. Therapeutics and Clinical Risk Management, 13, 1107-1117. https://doi.org/10.2147/TCRM.S119938
[5]
Balk, R. (2011) Roger C. Bone, MD and the Evolving Paradigms of Sepsis. Contributions to Microbiology, 17, 1-11. https://doi.org/10.1159/000323970
[6]
Bone, R.C., Grodzin, C.J. and Balk, R.A. (1997) Sepsis: A New Hypothesis for Pathogenesis of the Disease Process. Chest, 112, 235-243. https://doi.org/10.1378/chest.112.1.235
[7]
Tschaikowsky, K., Hedwig-Geissing, M., Schiele, A., et al. (2002) Coincidence of Pro- and Anti-Inflammatory Responses in the Early Phase of Sepsis: Longitudinal Study of Mononuclear Histocompatibility Leukocyte Antigen-DR Expression, Procalcitonin, C-Reactive Protein, and Changes in T-Cell Subsets in Septic and Postoperative Patients. Critical Care Medicine, 30, 1015-1023. https://doi.org/10.1097/00003246-200205000-00010
[8]
Zeitoun, A.A.H., Gad, S.S., Attia, F.M., et al. (2010) Evaluation of Neutrophilic CD64, Interleukin 10 and Procalcitonin as Diagnostic Markers of Early- and Late-Onset Neonatal Sepsis. Scandinavian Journal of Infectious Diseases, 42, 299-305. https://doi.org/10.3109/00365540903449832
[9]
Gryzunova, Yu.A. and Dobretsova, G.E. (1998) Dobretsov Albumin Serum Albumin in Clinical Medicine. GEOTAR, Moscow, 440 p.
[10]
Gerych, I.D., Bulavenko, O.V. and Ostapyuk, L.R. (2015) Fluorescence Spectroscopy: Possibilities of Application in Medical Practice. Liga-Press, Lviv, 366 p.
[11]
Ostapiuk, L. (2019) Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases. International Journal of Clinical Medicine, 10, 577-595. https://doi.org/10.4236/ijcm.2019.1011047
[12]
Bulavenko, O.V., Gerych, I.D., Ostapiuk, L.R., et al. (2013) Modeling of Blood Serum Changes in Patients with Various Diseases and Treatment Measures. Biomedical and Biosocial Anthropology, 20, 8-14.
[13]
Bulavenko, O., Ostapiuk, L., Rud, V., et al. (2021) Problems and Challenges to Women’s Reproductive Health in the 21st Century. Acta Scientific Women’s Health, No. 3, 70-87. https://doi.org/10.31080/ASWH.2021.SI.03.0012
[14]
Ostapiuk, L. (2022) The Pathogenetic Concept of the Diagnostic-Treatment Approach for Patients with Purulent-Septic Complications. International Journal of Clinical Medicine, 13, 1-21. https://doi.org/10.4236/ijcm.2022.131001
[15]
Zaporozhan, S., Savchyn, V., Ostapiuk, L., Voloshinovskii, A., Tuziuk, N. and Malyi, T. (2020) The New Approach to the Diagnostics and Treatment of Endogenous Intoxication in Patients with Burn Injury. International Journal of Clinical Medicine, 11, 375-388. https://doi.org/10.4236/ijcm.2020.116033
[16]
Ostapiuk, L., Voloshinovskii, A., Savchyn, V., Tuziyk, N. and Маlui, T. (2021) Current Problems of Diagnostics and Treatment of Purulent-Inflammatory Diseases and Sepsis in Medical Practice. International Journal of Clinical Medicine, 12, 87-107. https://doi.org/10.4236/ijcm.2021.123011
[17]
Trischitta, V. (2003) Relationship between Obesity-Related Metabolic Abnormalities and Sexual Function. Journal of Endocrinological Investigation, 26, 62-64.
