Background: Chronic inflammation of the joints in JIA patients is associated with raised levels of serum inflammatory biomarkers, which vary
according to disease activity. Neutrophil count, platelet count, mean platelet
volume (MPV), platelet distribution width (PDW), ESR and CRP are the essential
markers to evaluate the disease activity status of JIA patients. Objectives: To assess neutrophil count, platelet count, MPV, PDW, CRP and Juvenile
Arthritis Disease Activity Score (JADAS) in JIA patients and determine their
association at the initial visit and six months after treatment. Methods:
This prospective observational study was conducted from March 2019 to December
2020 in the department of paediatrics, Bangabandhu Sheikh Mujib Medical
University, Dhaka, Bangladesh. Fifty newly diagnosed JIA cases fulfilling the
ILAR classification criteria were included in the study. Disease activity was
assessed by JADAS 27. JADAS 27 and inflammatory biomarkers were measured at the
initial visit and six months of treatment and these were compared. Results: Mean neutrophil count, platelet count, and CRP significantly decreased at
follow-up after six months of treatment. MPV and PDW were increased after six
months compared to the initial visit, and the change was significant. Mean
JADAS 27 also decreased significantly at follow-up. Neutrophil count, Platelet
indices and CRP had a significant association with JADAS 27. Conclusion: In this study, neutrophil count, platelet indices, and CRP after six months of
treatment were improved. A significant association of JADAS 27 was found with
platelet indices, neutrophil count and CRP.
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