|
|
Hippo/YAP途径在肿瘤细胞信号通路交互调控中的作用
|
Abstract:
Hippo/YAP信号通路在维持组织动态平衡和器官再生中发挥重要作用。近几年，越来越多研究表明Hippo/YAP途径与其他肿瘤相关细胞信号通路交互调控，从而影响多种肿瘤的发生和发展过程。本文主要综述了Hippo/YAP信号通路的组成、调控机制，以及Hippo通路关键因子YAP在与其他肿瘤相关细胞信号通路交互调控中的功能及其分子机制。本文将为深入挖掘并揭示Hippo/YAP通路在肿瘤发生中的作用，并以此为开发靶向药物提供思路。
Hippo/YAP signaling pathway plays a decisive role in maintaining tissue homeostasis and organ regeneration. In recent years, more and more studies have shown that Hippo/YAP pathway crosstalk with other tumor-related cell signaling pathways, thus affecting the occurrence and development of various tumors. This paper mainly reviews the composition and regulatory mechanism of Hippo/YAP signaling pathway, as well as the function and molecular mechanism of YAP, a key factor of Hippo pathway, in crosstalk with other tumor-related cell signaling pathways. This paper will provide ideas for further exploring and revealing the role of Hippo/YAP pathway in tumorigenesis and thereby developing targeted drugs.
| [1] | Meng, Z., Moroishi, T. and Guan, K.L. (2016) Mechanisms of Hippo Pathway Regulation. Genes & Development, 30, 1-17. https://doi.org/10.1101/gad.274027.115 |
| [2] | Harvey, K.F., Zhang, X. and Thomas, D.M. (2013) The Hippo Pathway and Human Cancer. Nature Reviews Cancer, 13, 246-257. https://doi.org/10.1038/nrc3458 |
| [3] | Hansen, C.G., Moroishi, T. and Guan, K.L. (2015) YAP and TAZ: A Nexus for Hippo Signaling and Beyond. Trends in Cell Biology, 25, 499-513. https://doi.org/10.1016/j.tcb.2015.05.002 |
| [4] | Misra, J.R. and Irvine, K.D. (2018) The Hippo Signaling Network and Its Biological Functions. Annual Review of Genetics, 52, 65-87. https://doi.org/10.1146/annurev-genet-120417-031621 |
| [5] | Zhang, K., et al. (2015) YAP and TAZ Take Center Stage in Cancer. Biochemistry, 54, 6555-6566.
https://doi.org/10.1021/acs.biochem.5b01014 |
| [6] | Totaro, A., Panciera, T. and Piccolo, S. (2018) YAP/TAZ Upstream Signals and Downstream Responses. Nature Cell Biology, 20, 888-899. https://doi.org/10.1038/s41556-018-0142-z |
| [7] | Santoro, R., et al. (2020) Modulating TAK1 Expression Inhibits YAP and TAZ Oncogenic Functions in Pancreatic Cancer. Molecular Cancer Therapeutics, 19, 247-257. https://doi.org/10.1158/1535-7163.MCT-19-0270 |
| [8] | Dolcet, X., et al. (2005) NF-κB in Development and Progression of Human Cancer. Virchows Archiv, 446, 475-482.
https://doi.org/10.1007/s00428-005-1264-9 |
| [9] | Zhao, L., et al. (2018) YAP1 Is Essential for Osteoclastogenesis through a TEADs-Dependent Mechanism. Bone, 110, 177-186. https://doi.org/10.1016/j.bone.2018.01.035 |
| [10] | Caire, R., et al. (2021) YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast like Synoviocytes Phenotype and Fibro-Inflammatory Response. Frontiers in Immunology, 12, Article ID: 791907.
https://doi.org/10.3389/fimmu.2021.791907 |
| [11] | Ye, S., et al. (2018) YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis. Cancer Research, 78, 2705-2720. https://doi.org/10.1158/0008-5472.CAN-17-4052 |
| [12] | Rivera-Reyes, A., et al. (2018) YAP1 Enhances NF-κB-Dependent and Independent Effects on Clock-Mediated Unfolded Protein Responses and Autophagy in Sarcoma. Cell Death & Disease, 9, 1108.
https://doi.org/10.1038/s41419-018-1142-4 |
| [13] | Wang, J., et al. (2019) YAP Promotes the Malignancy of Endometrial Cancer Cells via Regulation of IL-6 and IL-11. Molecular Medicine, 25, 32. https://doi.org/10.1186/s10020-019-0103-4 |
| [14] | Zhao, T. and Wang, Z. (2022) HTLV-1 Activates YAP via NF-κB/p65 to Promote Oncogenesis. Proceedings of the National Academy of Sciences of the United States of America, 119, e2115316119.
https://doi.org/10.1073/pnas.2115316119 |
| [15] | Wang, Q., et al. (2018) REGγ Controls Hippo Signaling and Reciprocal NF-κB-YAP Regulation to Promote Colon Cancer. Clinical Cancer Research, 24, 2015-2025. https://doi.org/10.1158/1078-0432.CCR-17-2986 |
| [16] | Gao, Y., et al. (2017) TNFα-YAP/p65-HK2 Axis Mediates Breast Cancer Cell Migration. Oncogenesis, 6, e383.
https://doi.org/10.1038/oncsis.2017.83 |
| [17] | Rohban, M.H. and Singh, S. (2017) Systematic Morphological Profiling of Human Gene and Allele Function via Cell Painting. eLife, 6, e24060. https://doi.org/10.7554/eLife.24060 |
| [18] | Yang, B., et al. (2020) YAP1 Inhibits the Induction of TNF-α-Stimulated Bone-Resorbing Mediators by Suppressing the NF-κB Signaling Pathway in MC3T3-E1 Cells. Journal of Cellular Physiology, 235, 4698-4708.
https://doi.org/10.1002/jcp.29348 |
| [19] | Lv, Y., et al. (2018) YAP Controls Endothelial Activation and Vascular Inflammation through TRAF6. Circulation Research, 123, 43-56. https://doi.org/10.1161/CIRCRESAHA.118.313143 |
| [20] | LaCanna, R., et al. (2019) Yap/Taz Regulate Alveolar Regeneration and Resolution of Lung Inflammation. Journal of Clinical Investigation, 129, 2107-2122. https://doi.org/10.1172/JCI125014 |
| [21] | Zhang, Q., et al. (2018) Yes-Associated Protein (YAP) and Transcriptional Coactivator with PDZ-Binding Motif (TAZ) Mediate Cell Density-Dependent Proinflammatory Responses. Journal of Biological Chemistry, 293, 18071-18085.
https://doi.org/10.1074/jbc.RA118.004251 |
| [22] | Tang, K.M., et al. (2021) Role of the Hippo-YAP/NF-κB Signaling Pathway Crosstalk in Regulating Biological Behaviors of Macrophages under Titanium Ion Exposure. Journal of Applied Toxicology, 41, 561-571.
https://doi.org/10.1002/jat.4065 |
| [23] | Luo, X., et al. (2021) Hippo Pathway Counter-Regulates Innate Immunity in Hepatitis B Virus Infection. Frontiers in Immunology, 12, Article ID: 684424. https://doi.org/10.3389/fimmu.2021.684424 |
| [24] | Wang, S., et al. (2020) The Crosstalk between Hippo-YAP Pathway and Innate Immunity. Frontiers in Immunology, 11, 323. https://doi.org/10.3389/fimmu.2020.00323 |
| [25] | Caire, R., et al. (2022) YAP Transcriptional Activity Dictates Cell Response to TNF in Vitro. Frontiers in Immunology, 13, Article ID: 856247. https://doi.org/10.3389/fimmu.2022.856247 |
| [26] | Yu, F., et al. (2021) Wnt/β-Catenin Signaling in Cancers and Targeted Therapies. Signal Transduction and Targeted Therapy, 6, 307. https://doi.org/10.1038/s41392-021-00701-5 |
| [27] | Eisenmann, D.M. (2005) Wnt Signaling. WormBook. 1-17. https://doi.org/10.1895/wormbook.1.7.1 |
| [28] | Li, N., Lu, N. and Xie, C. (2019) The Hippo and Wnt Signalling Pathways: Crosstalk during Neoplastic Progression in Gastrointestinal Tissue. FEBS Journal, 286, 3745-3756. https://doi.org/10.1111/febs.15017 |
| [29] | Quinn, H.M., Vogel, R. and Popp, O. (2021) YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer. Cancer Research, 81, 2116-2127. https://doi.org/10.1158/0008-5472.CAN-20-2801 |
| [30] | Wang, Y., et al. (2017) β-Catenin-Mediated YAP Signaling Promotes Human Glioma Growth. Journal of Experimental & Clinical Cancer Research, 36, 136. https://doi.org/10.1186/s13046-017-0606-1 |
| [31] | Tang, X., et al. (2019) Knockdown of YAP Inhibits Growth in Hep-2 Laryngeal Cancer Cells via Epithelial-Mesenchymal Transition and the Wnt/β-Catenin Pathway. BMC Cancer, 19, Article No. 654.
https://doi.org/10.1186/s12885-019-5832-9 |
| [32] | Zeng, M., et al. (2021) CBX2 Depletion Inhibits the Proliferation, Invasion and Migration of Gastric Cancer Cells by Inactivating the YAP/β-Catenin Pathway. Molecular Medicine Reports, 23, 137.
https://doi.org/10.3892/mmr.2020.11776 |
| [33] | Deng, F., et al. (2018) YAP Triggers the Wnt/β-Catenin Signalling Pathway and Promotes Enterocyte Self-Renewal, Regeneration and Tumorigenesis after DSS-Induced Injury. Cell Death & Disease, 9, 153.
https://doi.org/10.1038/s41419-017-0244-8 |
| [34] | Wang, S., et al. (2019) LKB1 and YAP Phosphorylation Play Important Roles in Celastrol-Induced β-Catenin Degradation in Colorectal Cancer. Therapeutic Advances in Medical Oncology, 11, 1-19.
https://doi.org/10.1177/1758835919843736 |
| [35] | Liu, T., et al. (2019) The β-Catenin/YAP Signaling Axis Is a Key Regulator of Melanoma-Associated Fibroblasts. Signal Transduction and Targeted Therapy, 4, 63. https://doi.org/10.1038/s41392-019-0100-7 |
| [36] | Bisso, A., et al. (2020) Cooperation between MYC and β-Catenin in Liver Tumorigenesis Requires Yap/Taz. Hepatology, 72, 1430-1443. https://doi.org/10.1002/hep.31120 |
| [37] | Konsavage, W.M., et al. (2012) Wnt/β-Catenin Signaling Regulates Yes-Associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells. Journal of Biological Chemistry, 287, 11730-11739.
https://doi.org/10.1074/jbc.M111.327767 |
| [38] | Rosenbluh, J., et al. (2012) β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis. Cell, 151, 1457-1473. https://doi.org/10.1016/j.cell.2012.11.026 |
| [39] | Chen, C., et al. (2018) YAP-Dependent Ubiquitination and Degradation of β-Catenin Mediates Inhibition of Wnt Signalling Induced by Physalin F in Colorectal Cancer. Cell Death & Disease, 9, 591.
https://doi.org/10.1038/s41419-018-0645-3 |
| [40] | Azzolin, L., et al. (2014) YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response. Cell, 158, 157-170. https://doi.org/10.1016/j.cell.2014.06.013 |
| [41] | Massagué, J. (2008) TGFbeta in Cancer. Cell, 134, 215-230. https://doi.org/10.1016/j.cell.2008.07.001 |
| [42] | Ferrigno, O., et al. (2002) Yes-Associated Protein (YAP65) Interacts with Smad7 and Potentiates Its Inhibitory Activity against TGF-Beta/Smad Signaling. Oncogene, 21, 4879-4884. https://doi.org/10.1038/sj.onc.1205623 |
| [43] | Hiemer, S.E., Szymaniak, A.D. and Varelas, X. (2014) The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-Induced Tumorigenic Phenotypes in Breast Cancer Cells. Journal of Biological Chemistry, 289, 13461-13474. https://doi.org/10.1074/jbc.M113.529115 |
| [44] | Yan, X., He, Y. and Yang, S. (2022) A Positive Feedback Loop: RAD18-YAP-TGF-β between Triple-Negative Breast Cancer and Macrophages Regulates Cancer Stemness and Progression. Cell Death Discovery, 8, Article No. 196.
https://doi.org/10.1038/s41420-022-00968-9 |
| [45] | Du, X.X., et al. (2021) YAP/STAT3 Promotes the Immune Escape of Larynx Carcinoma by Activating VEGFR1-TGFβ Signaling to Facilitate PD-L1 Expression in M2-Like TAMs. Experimental Cell Research, 405, Article ID: 112655.
https://doi.org/10.1016/j.yexcr.2021.112655 |
| [46] | Sun, Q., et al. (2021) 25(OH)-Vitamin D Alleviates Neonatal Infectious Pneumonia via Regulating TGFβ-Mediated Nuclear Translocation Mechanism of YAP/TAZ. Bioengineered, 12, 8931-8942.
https://doi.org/10.1080/21655979.2021.1990000 |
| [47] | Ye, S., Liu, Y. and Fuller, A.M. (2020) TGFβ and Hippo Pathways Cooperate to Enhance Sarcomagenesis and Metastasis through the Hyaluronan-Mediated Motility Receptor (HMMR). Molecular Cancer Research, 18, 560-573.
https://doi.org/10.1158/1541-7786.MCR-19-0877 |
| [48] | Qi, Y.J., et al. (2020) Porphyromonas gingivalis Promotes Progression of Esophageal Squamous Cell Cancer via TGFβ-Dependent Smad/YAP/TAZ Signaling. PLOS Biology, 18, e3000825.
https://doi.org/10.1371/journal.pbio.3000825 |
| [49] | Fujii, M., et al. (2012) TGF-β Synergizes with Defects in the Hippo Pathway to Stimulate Human Malignant Mesothelioma Growth. Journal of Experimental Medicine, 209, 479-494. https://doi.org/10.1084/jem.20111653 |
| [50] | Zhuang, C., et al. (2020) Silencing of lncRNA MIR497HG via CRISPR/Cas13d Induces Bladder Cancer Progression Through Promoting the Crosstalk between Hippo/Yap and TGF-β/Smad Signaling. Frontiers in Molecular Biosciences, 7, Article ID: 616768. https://doi.org/10.3389/fmolb.2020.616768 |
| [51] | Lü？nd, F. and Pirkl, M. (2022) Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-Catenin Signaling in Melanoma Phenotype Switching. Life Science Alliance, 5, e202101010. https://doi.org/10.26508/lsa.202101010 |
| [52] | Sun, J.G., et al. (2016) Yap1 Promotes the Survival and Self-Renewal of Breast Tumor Initiating Cells via Inhibiting Smad3 Signaling. Oncotarget, 7, 9692-706. https://doi.org/10.18632/oncotarget.6655 |
| [53] | Chen, C.L., et al. (2013) Reciprocal Regulation by TLR4 and TGF-β in Tumor-Initiating Stem-Like Cells. Journal of Clinical Investigation, 123, 2832-2849. https://doi.org/10.1172/JCI65859 |
| [54] | Zhang, T., et al. (2014) Ellagic Acid Exerts Anti-Proliferation Effects via Modulation of Tgf-β/Smad3 Signaling in MCF-7 Breast Cancer Cells. Asian Pacific Journal of Cancer Prevention, 15, 273-276.
https://doi.org/10.7314/APJCP.2014.15.1.273 |
| [55] | Kumar, K.J., et al. (2015) Antrodin C Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Suppression of Smad2/3 and β-Catenin Signaling Pathways. PLOS ONE, 10, e0117111.
https://doi.org/10.1371/journal.pone.0117111 |
| [56] | Labibi, B., et al. (2020) Modeling the Control of TGF-β/Smad Nuclear Accumulation by the Hippo Pathway Effectors, Taz/Yap. iScience, 23, Article ID: 101416. https://doi.org/10.1016/j.isci.2020.101416 |
| [57] | Fernandez, L.A., et al. (2012) Oncogenic YAP Promotes Radioresistance and Genomic Instability in Medulloblastoma through IGF2-Mediated Akt Activation. Oncogene, 31, 1923-1937. https://doi.org/10.1038/onc.2011.379 |
| [58] | Jeong, S.H., et al. (2018) Hippo-Mediated Suppression of IRS2/AKT Signaling Prevents Hepatic Steatosis and Liver Cancer. Journal of Clinical Investigation, 128, 1010-1025. https://doi.org/10.1172/JCI95802 |
| [59] | Koo, J.H. and Plouffe, S.W. (2020) Induction of AP-1 by YAP/TAZ Contributes to Cell Proliferation and Organ Growth. Genes & Development, 34, 72-86. https://doi.org/10.1101/gad.331546.119 |
| [60] | He, L., Pratt, H. and Gao, M. (2021) YAP and TAZ Are Transcriptional Co-Activators of AP-1 Proteins and STAT3 during Breast Cellular Transformation. eLife, 10, e67312. https://doi.org/10.1101/2021.02.18.431832 |
| [61] | Slemmons, K.K., et al. (2017) A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. Molecular Cancer Research, 15, 1777-1791. https://doi.org/10.1158/1541-7786.MCR-17-0004 |
| [62] | Chan, L.H., et al. (2014) Hedgehog Signaling Induces Osteosarcoma Development through Yap1 and H19 Overexpression. Oncogene, 33, 4857-4866. https://doi.org/10.1038/onc.2013.433 |
| [63] | Tariki, M., et al. (2014) The Yes-Associated Protein Controls the Cell Density Regulation of Hedgehog Signaling. Oncogenesis, 3, e112. https://doi.org/10.1038/oncsis.2014.27 |
