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13C-美沙西丁的制备研究进展
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Abstract:
目的：为13C-美沙西丁的合成方法进行总结并提供参考。方法：本文通过查阅相关文献，系统归纳了13C-美沙西丁各种合成方法在安全性、产率、经济性、工艺复杂程度等方面的优缺点。结果与结论：13C-美沙西丁现有的制备方式多为用13C-碘甲烷、13C-甲醇、13C-硫酸二甲酯等甲基化试剂与对乙酰氨基酚反应获得。采用Mitsunobu醚化反应制备13C-美沙西丁，反应物毒性低、产率和纯度较高、反应流程比较简单，是一种合适的方法，有着广阔的发展前景。
Objective: To summarize and provide a reference for the synthetic methods of 13C-Methacetin. Methods: This paper systematically summarized the advantages and disadvantages of various synthetic methods of 13C-Methacetin in terms of safety, yield, economy, process complexity, etc. Results and Conclusion: The existing methods of preparation of 13C-Methacetin are mostly obtained by reaction of 13C-iodomethane, 13C-methanol, 13C-dimethyl sulfate and other methylating agents with acetaminophen. Using Mitsunobu etherification reaction to prepare 13C-Methacetin is a suitable method with low toxicity, high yield and purity of reactants, and simple reaction process. It is an appropriate method and has broad development prospects.
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