拉贝洛尔对早发型重度子痫前期患者子宫螺旋动脉血流动力学、胎盘微血管密度影响研究
Effects of Labetalol on Uterine Spiral Artery Hemodynamics and Placental Microvessel Density in Patients with Early Onset Severe Preeclampsia

目的：早发型重度子痫前期患者应用拉贝洛尔治疗的影响分析。方法：随机抽取2019年4月至2020年5月间收治的早发型重度子痫前期患者54例，随机分为对照组和实验组，分别予以硫酸镁 + 硝苯地平、硫酸镁 + 拉贝洛尔，对比两组治疗后子宫螺旋动脉血流动力学及胎盘微血管密度。结果：治疗5 d后实验组Vs、Vd高于对照组，且PI、RI、S/D低于对照组，实验组不同发病时期胎盘微血管密度高于对照组，P < 0.05。结论：早发型重度子痫前期患者应用拉贝洛尔可改善其子宫血供及胎盘状态，值得推广。
Objective: Analysis of the effect of labetalol treatment in patients with early onset severe preeclampsia. Methods: A total of 54 patients with early onset severe preeclampsia treated in our hospital from April 2019 to May 2020 were randomly selected and divided into the control group and the experimental group, which were treated with magnesium sulfate + nifedipine and magnesium sulfate + labetalol, respectively. The uterine spiral artery hemodynamics and pla-cental microvessel density were compared between the two groups after treatment. Results: After 5 days of treatment, Vs and Vd in the experimental group were higher than those in the control group, and PI, RI, S/D were lower than those in the control group. The placental microvessel density in the experimental group was higher than that in the control group at different stages of the disease (P < 0.05). Conclusion: Labetalol can improve uterine blood supply and placental status in patients with early onset severe preeclampsia, which is worthy of promotion.