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光学相干断层扫描血管成像技术在原发性闭角型青光眼中的诊断应用
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Abstract:
青光眼在病变过程中视网膜微循环的变化情况受到众多学者的关注，光学相干断层成像血管造影(OCTA)是一项非侵入式的全新成像技术，可用于评估视网膜和脉络膜血管系统。最近的研究表明，OCTA对视网膜微循环改变的评估主要在视盘旁区和黄斑区。青光眼患者视盘旁区全层和RPC血管密度显著下降，并与疾病严重程度相关；黄斑区则呈现血管密度下降，无血管区面积显著增大的趋势。总体来看，可以为青光眼视网膜微循环评估提供新的技术手段，并强调这项新技术在青光眼领域的潜在应用。本文从视网膜微循环的表现以及青光眼视网膜微循环的图像改变，包括青光眼视盘旁区微循环改变、黄斑区微循环改变、评估青光眼黄斑区与视盘旁区微循环的影响因素及诊断价值比较几个方面就OCTA对青光眼视网膜微循环的评估研究进展进行综述。
The changes of retinal microcirculation in the course of glaucoma disease have attracted the attention of many scholars. Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique, which can be used to evaluate the retinal and choroidal vascular system. Recent studies have shown that OCTA’s evaluation of retinal microcirculation changes is mainly in the para-optic area and macular area. In patients with glaucoma, whole-layer and RPC vessel density decreased significantly, which was correlated with disease severity. In the macular area, the blood vessel density decreased and the area without blood vessel increased significantly. Overall, it provides a new technique for the evaluation of retinal microcirculation in glaucoma and highlights the potential application of this new technique in the field of glaucoma. This paper reviews the progress of OCTA in the evaluation of retinal microcirculation in glaucoma from the aspects of the manifestations of retinal microcirculation and the image changes of retinal microcirculation in glaucoma, including the changes of microcirculation in the para-optic area of glaucoma, the changes of microcirculation in the macular area of glaucoma, the evaluation of influencing factors of microcirculation in the macular area and the para-optic area of glaucoma, and the comparison of diagnostic value.
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