Clinical Significance of Serum Uric Acid Combined with Cystatin C Detection in Patients with Different Levels of Hypertension with High Risk Degree and Above
Objective: To explore the clinical significance of serum uric acid combined with cystatin C detection in high risk degree of hypertension of different grades. Methods: The patients who were treated in the Department of Cardiovascular Medicine of our hospital from January to December 2022 were selected as the study subjects, and the high risk and extremely high risk groups of grade I, II and III hypertension were selected for comparative analysis to explore their clinical significance. Results: There was a statistically significant difference in the number of patients with extremely high risk of grade II hypertension between men and women (P < 0.05), which showed that the prevalence rate of women with extremely high risk of grade II hypertension was higher than that of men; compared with the number of patients with high risk of grade III hypertension, the difference was statistically significant (P < 0.05), which showed that the prevalence rate of men with high risk of grade III hypertension was higher than that of women. The concentrations of serum uric acid and cystatin C were compared in groups with high risk of hypertension grade I, II and III; and the difference was not statistically significant (P > 0.05), which showed that there was no specificity in the concentration detection of serum uric acid and cystatin C in different grades of hypertension; there was no significant difference in serum uric acid concentration between grade II and grade III of hypertension with high risk grade and cystatin C concentration between grade I and grade III of hypertension with high risk grade (P > 0.05), but there was significant difference in the concentration detection of serum uric acid and cystatin C between the other groups (P < 0.05), which indicates that the detection of serum uric acid and cystatin C has important clinical significance in the high risk degree of hypertension. Conclusion: In the comparison of the detection of blood uric acid and cystatin C in different levels of hypertension with extremely high risk, the difference of cystatin C in grade I and grade III was not statistically significant, and the rest were statistically significant; therefore, the detection of serum uric acid and cystatin C can provide reliable laboratory data for clinical diagnosis and treatment of the extremely high risk degree of different levels of hypertension.
References
[1]
Chen, T. (2021) The Research of Clinical Value of Serum Cystatin C Combined with Homocysteine Detection in the Diagnosis of Hypertensive with Early Nephropathy. China Practical Medicine, 16, 14-16.
[2]
Wang, X.H., Yang, H.J., Hu, X.H., et al. (2021) Clinical Significance of Serum Cystatin C Combined with Homocysteine Detection for Early Hypertensive Nephropathy. Chinese Journal of Clinicians, 49, 63-65.
[3]
Zhang, P. and Wang, Q.J. (2017) The Significance of Combined Detection of Serum Cystatin C and Homocysteine in the Diagnosis of Early Hypertensive Nephropathy. Electronic Journal of Clinical Medical Literature, 4, 20131.
[4]
Wang, H.M. (2015) To Explore the Clinical Value of Combined Detection of Serum Cystatin C and Homocysteine in the Diagnosis of Early Hypertensive Nephropathy. Intelligent Health, 1, 44-46.
[5]
Jiang, Y., Liu, R.S., Li, Y., et al. (2015) The Significance of Combined Detection of Serum Cystatin C and Homocysteine in the Diagnosis of Early Hypertensive Nephropathy. Chongqing Medical Journal, 44, 1193-1196.
[6]
Yu, Y., Zhang, M. and Wang, J. (2023) The Significance of Serum Cystatin C and Urine Kidney Injury Molecule-1 in Evaluating the Degree of Renal Tubulointerstitial Injury in Patients with Hypertensive Disorder Complicating Pregnancy. China Maternal and Child Health Research, 34, 34-39.
[7]
Tao, C. and Chen, X.X. (2022) Clinical Value of Cystatin C and Uric Acid in the Diagnosis of Renal Injury in Hypertensive Disorder Complicating Pregnancy. Chinese Medical Science, 12, 88-91.
[8]
Chen, X. (2022) Correlation between Serum Cystatin C Level and Vascular Endothelial Function in Hypertensive Patients with Metabolic Syndrome and Simple Hypertension. Jilin Medical Journal, 43, 47-50.
[9]
Liu, H.H. and Shen, X.M. (2017) Analysis of the Correlation between Serum Cystatin C and Vascular Endothelial Function in Patients with Hypertension and Metabolic Syndrome. Journal of Cardiovascular and Cerebrovascular Diseases Combined with Traditional Chinese and Western Medicine, 15, 1755-1758.
[10]
Liu, H.H. (2017) Correlation between Serum Cystatin C and Vascular Endothelial Function in Hypertensive Patients with Metabolic Syndrome. Shanxi Medical University, Taiyuan.
[11]
Wang, J.Y. (2021) Diagnostic Value of Serum Cystatin C and Urine Kidney Damage Molecule-1 in Early Renal Injury in Hypertensive Patients during Pregnancy. Journal of Clinical Research, 29, 119-122.
[12]
Wu, N.S., Dengm, G.H. and Li, Q. (2018) Correlation Analysis of Serum Hcy, UA, Cystatin C Levels and Carotid Atherosclerosis in Patients with Acute Cerebral Infarction and Type H Hypertension. Medical Theory and Practice, 31, 1107-1109.
[13]
Kou, Z.L., Xu, X., Yang, K.Y., et al. (2021) Study on the Correlation between TCM Syndrome Types and Cystatin C in Hypertension Patients with Diabetes. Clinical Research of Traditional Chinese Medicine, 13, 18-21.
[14]
Wang, R., Hu, R.L. and Chen, H.L. (2021) Study on the Changes of Blood Urea Nitrogen, Creatinine, Uric Acid and Cystatin C Levels in Elderly Hypertensive Patients. Chinese and Foreign Medical Research, 19, 80-82.
[15]
Zhou, J., Yao, W.W. and Xu, X.X. (2017) Characteristics and Clinical Significance of Serum Cystatin C, Blood Urea Nitrogen and Blood Creatinine in Elderly Hypertensive Patients. Systematic Medicine, 2, 4-7.
[16]
Zhang, Y., Su, J.L., Lu, C.X., et al. (2021) Clinical Significance of Detection of Serum Cystatin C and Urine Kidney Injury Molecule-1 in Patients with Early Renal Injury of Hypertensive Disorder Complicating Pregnancy. China Contemporary Medicine, 28, 33-35.
[17]
Chen, S.P. (2021) The Diagnostic Value of Serum Cystatin C and Urine Kidney Injury Molecule-1 Detection for Early Renal Injury in Patients with Hypertensive Disorder Complicating Pregnancy. China Maternal and Child Health Care, 36, 555-557.
[18]
Xie, S.Q., Gong, M., Liu, W., et al. (2019) Clinical Significance of Detection of Serum Cystatin C and Urine Kidney Injury Molecule-1 in Patients with Early Renal Injury of Hypertensive Disorder Complicating Pregnancy. Journal of Experimental and Laboratory Medicine, 37, 356-357+371.
[19]
Zhu, D.D., Wang, C.C. and Wang, Y.Y. (2021) Correlation between Blood Uric Acid Level and Hypertensive Nephropathy in Hypertensive Patients. Chinese Journal of Gerontology, 41, 4884-4887.
[20]
Mai, Y.B. and Li, X.W. (2016) Study on the Correlation between Blood Uric Acid Level and Hypertension in Acute Stage of Patients with Ischemic Stroke under the Age of 60. Henan Medical Research, 25, 1354-1356.
[21]
Lou, H. (2014) Correlation and Clinical Significance of Blood Uric Acid Level and Hypertension in Maintenance Hemodialysis Patients. China Practical Medicine, 9, 98-99.
[22]
Huang, H.C., Ke, X., Xie, G.S., et al. (2021) Study on the Value of Combined Detection of CysCand Hcy in the Diagnosis of Hypertensive Nephropathy in Elderly Patients. Chinese Journal of Medical Sciences, 11, 163-166.
