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毛鼠刺的化学成分研究
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Abstract:
目的：研究毛鼠刺Itea indochinensis Meer的化学成分。方法：综合利用多种色谱技术对毛鼠刺枝叶的化学成分进行分离纯化，基于波谱数据分析并结合文献比对完成结构鉴定。结果：从毛鼠刺枝叶的乙酸乙酯部位中共分离鉴定7个化合物，分别为7-ketositosterol (1)、stigmast-4-en-6β-ol-3-one (2)、β-谷甾醇(3)、植物醇(4)、十四烷酸(5)、Balansenate I (6)、三十一烷醇(7)。结论：所有化合物均为首次从该植物中分离得到。
Objective: To study the chemical constituents of Itea indochinensis. Methods: Various chromatographic methods were used to separate and purify compounds from the branches and leaves of Itea indochinensis. Their structures were elucidated by spectral analyses in combination with comparison to literature data. Results: Compounds were identified as 7-ketositosterol (1), stigmast-4-en-6β-ol-3-one (2), β-sitosterol (3), phytol (4), myristic acid (5), Balansenate I (6), n-hentriaconly alcohol (7) from the ethyl acetate soluble fraction of Itea indochinensis. Conclusion: All compounds are identified from the Itea indochinensis for the first time.
| [1] | Huang, B.S. and Zhang, Y. (2022) Teaching an Old Dog New Tricks: Drug Discovery by Repositioning Natural Prod-ucts and Their Derivatives. Drug Discovery Today, 27, 1936-1944. https://doi.org/10.1016/j.drudis.2022.02.007 |
| [2] | Davison, E.K. and Brimble, M.A. (2019) Natural Product De-rived Privileged Scaffolds in Drug Discovery. Current Opinion in Chemical Biology, 52, 1-8. https://doi.org/10.1016/j.cbpa.2018.12.007 |
| [3] | Newman, D.J. and Cragg, G.M. (2020) Natural Product as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. Journal of Natural Products, 83, 770-803. https://doi.org/10.1021/acs.jnatprod.9b01285 |
| [4] | 张惠源, 赵润怀, 袁昌齐, 等. 我国的中药资源种类[J]. 中国中药杂志, 1995(7): 387-390. |
| [5] | 陈凯先, 张卫东. 中药现代化与中药创新[J]. 中国食品药品监管, 2022(8): 4-13. |
| [6] | 中国科学院中国植物志编辑委员会. 中国植物志[M]. 北京: 科学出版社, 1995. |
| [7] | Luo, G.Y., Zhou, M., Liu, Y., et al. (2014) 3-Formyl-2-arylbenzofurans from the Aerial Parts of Itea ilicifolia. Phytochemistry Letters, 10, 19-22. https://doi.org/10.1016/j.phytol.2014.06.019 |
| [8] | Lang, T.Q., Luo, G.Y., Pu, W.C., et al. (2022) Three New 3-Formyl-2-arylbenz-ofurans from Itea yunnanensis and Their Anti-Hepatocellular Carcinoma Effects. Nat-ural Product Research, 36, 1205-1214.
https://doi.org/10.1080/14786419.2020.1867130 |
| [9] | 何江波, 康大伟, 牛燕芬, 等. 红毛悬钩子化学成分及其抗肿瘤活性[J]. 中成药, 2023, 45(1): 106-112. |
| [10] | 邵泰明, 宋小平, 陈光英, 等. 大果榕茎化学成分研究[J]. 中草药, 2013, 44(16): 2208-2212. |
| [11] | 马斌, 娄红祥, 孔令义. 硬指叶苔化学成分的研究[J]. 中草药, 2006, 37(5): 660-662. |
| [12] | 吕玲玉, 史高峰, 李春雷, 等. 甘薯叶化学成分研究[J]. 中药材, 2009, 32(6): 896-897. |
| [13] | Tsai, Y.-H., Chen, I.-S. and Tsai, I.-L. (2003) New Long-Chain Esters and Adenine Analogs from the Leaves of Formosan Bridelia balansae. Helvetica Chimica Acta, 86, 2452-2457. https://doi.org/10.1002/hlca.200390198 |
| [14] | 崔研, 孙铭学, 高焕焕, 等. 钩吻根脂溶性化学成分的分离与鉴定[J]. 沈阳药科大学学报, 2014, 31(4): 248-251+324. |
| [15] | 袁亚敏, 周晓欢, 王凤霞, 等. 椿根皮的化学成分及抑菌活性研究[J]. 广西植物, 2023, 43(1): 190-198. |
| [16] | 白兵. 肉豆蔻酸抗单核细胞增多性李斯特菌的活性及机制研究[D]: [硕士学位论文]. 长春: 吉林大学, 2017. |
| [17] | 苏生, 张莉, 杜文林, 等. 豆科植物多花木蓝抑菌活性成分研究[J]. 植物保护, 2017, 43(1): 121-125. |
| [18] | Islam, M.T., Ayatollahi, S.A., Zihad, S.M.N.K., et al. (2020) Phytol Anti-Inflammatory Activity: Pre-Clinical Assessment and Possi-ble Mechanism of Action Elucidation. Cellular Molecular Biology, 66, 264-269.
https://doi.org/10.14715/cmb/2020.66.4.31 |
| [19] | 赵宁东, 张博, 蒋金和, 等. 药用植物狗骨柴的化学成分及生物活性研究进展[J]. 安徽农业科学, 2009, 37(12): 5485-5487. |
| [20] | 陈元堃, 曾奥, 罗振辉, 等. β-谷甾醇药理作用研究进展[J]. 广东药科大学学报, 2021, 37(1): 148-153. |
